CHICK:ACAC

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ACAC
Protein Name(s)	Acetyl-CoA carboxylase ACC Biotin carboxylase
External Links
UniProt	P11029
EMBL	J03541 X05019
PIR	A29924
RefSeq	NP_990836.1
UniGene	Gga.1480
ProteinModelPortal	P11029
SMR	P11029
BioGrid	676751
PaxDb	P11029
PRIDE	P11029
GeneID	396504
KEGG	gga:396504
CTD	31
eggNOG	COG0511
HOVERGEN	HBG005371
InParanoid	P11029
KO	K11262
PhylomeDB	P11029
SABIO-RK	P11029
UniPathway	UPA00655
NextBio	20816543
PRO	PR:P11029
Proteomes	UP000000539
GO	GO:0005623 GO:0005737 GO:0003989 GO:0005524 GO:0004075 GO:0046872 GO:0006633 GO:2001295
Gene3D	3.30.1490.20 3.30.470.20 3.40.50.20 3.90.226.10
InterPro	IPR013537 IPR011761 IPR013815 IPR013816 IPR001882 IPR011764 IPR005482 IPR000089 IPR005481 IPR000022 IPR005479 IPR029045 IPR011763 IPR011762 IPR016185 IPR011054 IPR011053
Pfam	PF08326 PF02785 PF00364 PF01039 PF00289 PF02786
SMART	SM00878
SUPFAM	SSF51230 SSF51246 SSF52096 SSF52440
PROSITE	PS50975 PS50979 PS00188 PS50968 PS50989 PS50980 PS00866 PS00867

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0005524	ATP binding	PMID:6119314^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004075	biotin carboxylase activity	PMID:6119314^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	PMID:6119314^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0009374	biotin binding	PMID:2879745^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097066	response to thyroid hormone	PMID:11027684^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050692	DBD domain binding	PMID:11027684^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009743	response to carbohydrate	PMID:8870677^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	PMID:8870677^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001295	malonyl-CoA biosynthetic process	PMID:13998335^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0009374	biotin binding	PMID:13998335^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:13998335^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	PMID:13998335^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0065008	regulation of biological quality	PMID:20816383^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	PMID:20816383^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20816383^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16931873^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050692	DBD domain binding	PMID:16931873^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:20802119^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013537	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005479 InterPro:IPR011761 InterPro:IPR013537 InterPro:IPR013815	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013537	P		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011763	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011761	F		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.4.1.2	F		Seeded From UniProt	complete
enables	GO:0004075	biotin carboxylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.3.4.14	F		Seeded From UniProt	complete
involved_in	GO:2001295	malonyl-CoA biosynthetic process	PMID:6119314^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	PMID:6119314^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	PMID:6119314^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:2893793^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:0032868	response to insulin	PMID:11027684^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	PMID:8870677^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006810	transport	PMID:20816383^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	PMID:16931873^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032810	sterol response element binding	PMID:16931873^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:16931873^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:2001295	malonyl-CoA biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00655	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Beaty, NB & Lane, MD (1982) Acetyl coenzyme A carboxylase. Rapid purification of the chick liver enzyme and steady state kinetic analysis of the carboxylase-catalyzed reaction. J. Biol. Chem. 257 924-9 PubMed GONUTS page
↑ Takai, T et al. (1987) Primary structure of the biotin-binding site of chicken liver acetyl-CoA carboxylase. FEBS Lett. 212 98-102 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Zhang, Y et al. (2001) Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element. J. Biol. Chem. 276 974-83 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Hillgartner, FB et al. (1996) Alterations in nutritional status regulate acetyl-CoA carboxylase expression in avian liver by a transcriptional mechanism. Biochem. J. 319 ( Pt 1) 263-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 WAITE, M & WAKIL, SJ (1963) Studies on the mechanism of action of acetyl coenzyme A carboxylase. I. Effect of isocitrate on the transcarboxylation step of acetyl coenzyme A carboxylase. J. Biol. Chem. 238 77-80 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Hu, G et al. (2010) Epistatic effect between ACACA and FABP2 gene on abdominal fat traits in broilers. J Genet Genomics 37 505-12 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Talukdar, S & Hillgartner, FB (2006) The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. J. Lipid Res. 47 2451-61 PubMed GONUTS page
↑ Walter, I et al. (2010) AMP-activated protein kinase controls metabolism and heat production during embryonic development in birds. J. Exp. Biol. 213 3167-76 PubMed GONUTS page
↑ Takai, T et al. (1988) Primary structure of chicken liver acetyl-CoA carboxylase deduced from cDNA sequence. J. Biol. Chem. 263 2651-7 PubMed GONUTS page

[PMID:6119314-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Beaty, NB & Lane, MD (1982) Acetyl coenzyme A carboxylase. Rapid purification of the chick liver enzyme and steady state kinetic analysis of the carboxylase-catalyzed reaction. J. Biol. Chem. 257 924-9 PubMed GONUTS page

[PMID:2879745-2] Takai, T et al. (1987) Primary structure of the biotin-binding site of chicken liver acetyl-CoA carboxylase. FEBS Lett. 212 98-102 PubMed GONUTS page

[PMID:11027684-3] 3.0 ^3.1 ^3.2 Zhang, Y et al. (2001) Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element. J. Biol. Chem. 276 974-83 PubMed GONUTS page

[PMID:8870677-4] 4.0 ^4.1 ^4.2 Hillgartner, FB et al. (1996) Alterations in nutritional status regulate acetyl-CoA carboxylase expression in avian liver by a transcriptional mechanism. Biochem. J. 319 ( Pt 1) 263-8 PubMed GONUTS page

[PMID:13998335-5] 5.0 ^5.1 ^5.2 ^5.3 WAITE, M & WAKIL, SJ (1963) Studies on the mechanism of action of acetyl coenzyme A carboxylase. I. Effect of isocitrate on the transcarboxylation step of acetyl coenzyme A carboxylase. J. Biol. Chem. 238 77-80 PubMed GONUTS page

[PMID:20816383-6] 6.0 ^6.1 ^6.2 ^6.3 Hu, G et al. (2010) Epistatic effect between ACACA and FABP2 gene on abdominal fat traits in broilers. J Genet Genomics 37 505-12 PubMed GONUTS page

[PMID:16931873-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Talukdar, S & Hillgartner, FB (2006) The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. J. Lipid Res. 47 2451-61 PubMed GONUTS page

[PMID:20802119-8] Walter, I et al. (2010) AMP-activated protein kinase controls metabolism and heat production during embryonic development in birds. J. Exp. Biol. 213 3167-76 PubMed GONUTS page

[PMID:2893793-9] Takai, T et al. (1988) Primary structure of chicken liver acetyl-CoA carboxylase deduced from cDNA sequence. J. Biol. Chem. 263 2651-7 PubMed GONUTS page

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CHICK:ACAC

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