CAVPO:BACE1

Species (Taxon ID)	Cavia porcellus (Guinea pig). (10141)
Gene Name(s)	BACE1
Protein Name(s)	Beta-secretase 1 Beta-site amyloid precursor protein cleaving enzyme 1 Beta-site APP cleaving enzyme 1 Memapsin-2 Membrane-associated aspartic protease 2
External Links
UniProt	Q1KLR6
EMBL	DQ471956
RefSeq	NP_001166390.1
ProteinModelPortal	Q1KLR6
SMR	Q1KLR6
STRING	10141.ENSCPOP00000011476
MEROPS	A01.004
Ensembl	ENSCPOT00000012877
GeneID	100135485
CTD	23621
eggNOG	NOG71700
GeneTree	ENSGT00760000118929
HOGENOM	HOG000036572
HOVERGEN	HBG059578
InParanoid	Q1KLR6
OMA	VEGPFIT
OrthoDB	EOG7DNNVW
TreeFam	TF329595
Proteomes	UP000005447
GO	GO:0030424 GO:0009986 GO:0030659 GO:0005783 GO:0005768 GO:0005794 GO:0005887 GO:0005771 GO:0005802 GO:0004190 GO:0001540 GO:0050435 GO:0006508
Gene3D	2.40.70.10
InterPro	IPR001461 IPR001969 IPR009119 IPR009120 IPR021109
PANTHER	PTHR13683
Pfam	PF00026
PRINTS	PR01816 PR01815 PR00792
SUPFAM	SSF50630
PROSITE	PS00141

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050435	amyloid-beta metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56818	C		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001461 InterPro:IPR001969 InterPro:IPR009119 InterPro:IPR009120	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009119 InterPro:IPR009120	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0064	F		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
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References

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