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CANO9:H8WVX6

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Species (Taxon ID) Candida orthopsilosis (strain 90-125) (Yeast). (1136231)
Gene Name(s) No Information Provided.
Protein Name(s) Not4 E3 ubiquitin-protein ligase (ECO:0000313 with EMBL:CCG20600.1)
External Links
UniProt H8WVX6
EMBL HE681719
RefSeq XP_003866040.1
GeneID 14537652
KEGG cot:CORT_0A02090
KO K10643
OrthoDB EOG7FNCKC
Proteomes UP000005018
GO GO:0016874
GO:0000166
GO:0003723
GO:0008270
Gene3D 3.30.40.10
3.30.70.330
InterPro IPR012677
IPR000504
IPR000571
IPR001841
IPR013083
SMART SM00184
SM00360
PROSITE PS50102
PS50103
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010992

ubiquitin homeostasis

PMID:21321079[1]

ECO:0000315

P

Figure 1 demonstrates the importance of Not4 for ubiquitin homeostasis in a cell. In normal wild type cells with Not4 ubiquitin levels were stable, but in cells lacking Not4 there was a reduction in production of ubiquitin and increased synthesis leading to cell death. Without Not4 to regulate homeostasis, ubiquitin levels were unregulated causing cell death.

complete
CACAO 9865

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004842

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR003954
InterPro:IPR035979

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039780

F

Seeded From UniProt

complete

part_of

GO:0030014

CCR4-NOT complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039780

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000571

F

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000414619

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Panasenko, OO & Collart, MA (2011) Not4 E3 ligase contributes to proteasome assembly and functional integrity in part through Ecm29. Mol. Cell. Biol. 31 1610-23 PubMed GONUTS page