CANFA:RPE65

Species (Taxon ID)	Canis familiaris (Dog) (Canis lupus familiaris). (9615)
Gene Name(s)	RPE65
Protein Name(s)	Retinoid isomerohydrolase All-trans-retinyl-palmitate hydrolase Retinal pigment epithelium-specific 65 kDa protein Retinol isomerase
External Links
UniProt	Q9TVB8
EMBL	AF084537 Y16567 AJ506754 AJ506755 AJ506756 AJ506757 AJ251207 AJ506759
RefSeq	NP_001003176.1
UniGene	Cfa.3665
ProteinModelPortal	Q9TVB8
GeneID	403803
KEGG	cfa:403803
CTD	6121
eggNOG	COG3670
HOGENOM	HOG000232156
HOVERGEN	HBG050679
InParanoid	Q9TVB8
KO	K11158
NextBio	20817300
Proteomes	UP000002254
GO	GO:0005783 GO:0031090 GO:0005886 GO:0052885 GO:0052884 GO:0016853 GO:0046872 GO:0050896 GO:0007601
InterPro	IPR004294
PANTHER	PTHR10543
Pfam	PF03055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0001523	retinoid metabolic process	PMID:16150724^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	PMID:16150724^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16518	P	Seeded From UniProt	complete
enables	GO:0052884	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16518	F	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16518	C	Seeded From UniProt	complete
enables	GO:0004744	retinal isomerase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91ZQ5	F	Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16518	F	Seeded From UniProt	complete
enables	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9YGX2	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28175	C	Seeded From UniProt	complete
enables	GO:1901612	cardiolipin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28175	F	Seeded From UniProt	complete
enables	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28175	F	Seeded From UniProt	complete
enables	GO:0031210	phosphatidylcholine binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28175	F	Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28175	F	Seeded From UniProt	complete
involved_in	GO:1901827	zeaxanthin biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16518	P	Seeded From UniProt	complete
involved_in	GO:1901827	zeaxanthin biosynthetic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002576077 UniProtKB:Q16518 UniProtKB:Q9YGX2	P	Seeded From UniProt	complete
enables	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002576077 RGD:621396 UniProtKB:Q28175 UniProtKB:Q9YGX2	F	Seeded From UniProt	complete
enables	GO:0050251	retinol isomerase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002576077 UniProtKB:A9C3R8	F	Seeded From UniProt	complete
involved_in	GO:0042574	retinal metabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002937 MGI:MGI:1926923 MGI:MGI:2177469 MGI:MGI:98001 PANTHER:PTN000057192 RGD:621396 UniProtKB:Q9I993	P	Seeded From UniProt	complete
enables	GO:0004744	retinal isomerase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002937 MGI:MGI:98001 PANTHER:PTN000830314 UniProtKB:Q28175	F	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0052884	P	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0052885	P	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0052885	P	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0052885	P	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0052885	P	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0052884	P	Seeded From UniProt	complete
enables	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004294	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004294	P	Seeded From UniProt	complete
enables	GO:0052884	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.1.64	F	Seeded From UniProt	complete
enables	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.1.64	F	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0844	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C	Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Redmond, TM et al. (2005) Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. Proc. Natl. Acad. Sci. U.S.A. 102 13658-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16150724-1] 1.0 ^1.1 Redmond, TM et al. (2005) Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. Proc. Natl. Acad. Sci. U.S.A. 102 13658-63 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CANFA:RPE65

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