CANFA:PDE6A

Species (Taxon ID)	Canis familiaris (Dog) (Canis lupus familiaris). (9615)
Gene Name(s)	PDE6A (synonyms: PDEA)
Protein Name(s)	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha GMP-PDE alpha
External Links
UniProt	Q28263
EMBL	Z68340 U52868 Y13282
RefSeq	NP_001003073.1
UniGene	Cfa.1198
ProteinModelPortal	Q28263
STRING	9615.ENSCAFP00000011716
BindingDB	Q28263
ChEMBL	CHEMBL5151
PaxDb	Q28263
GeneID	403620
KEGG	cfa:403620
CTD	5145
eggNOG	NOG242608
HOGENOM	HOG000007069
HOVERGEN	HBG053539
InParanoid	Q28263
KO	K08718
Reactome	REACT_174228 REACT_174305 REACT_175273
NextBio	20817125
Proteomes	UP000002254
GO	GO:0005886 GO:0047555 GO:0046872 GO:0051480 GO:0046037 GO:0060041 GO:0007165 GO:0007601
Gene3D	1.10.1300.10 3.30.450.40
InterPro	IPR003018 IPR029016 IPR003607 IPR023088 IPR002073 IPR023174
Pfam	PF01590 PF00233
PRINTS	PR00387
SMART	SM00065 SM00471
SUPFAM	SSF55781
PROSITE	PS00126

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050908	detection of light stimulus involved in visual perception	PMID:18775863	ECO:0000315			P		Figure 4: Average dark adapted a- and b- ERG wave amplitudes from mutant PDE6A puppies peaked at three weeks of age and were significantly smaller than control puppies of the same age. Mean light adapted a-wave amplitudes of affected dogs were lower than normal dogs at 3 weeks of age and decreased with increasing age.	complete CACAO 4054
involved_in	GO:0060041	retina development in camera-type eye		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97524 PANTHER:PTN002602882	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002602882 UniProtKB:P16499	P		Seeded From UniProt	complete
enables	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002602882 UniProtKB:P16499	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002602882 UniProtKB:P16499	P		Seeded From UniProt	complete
enables	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002073 InterPro:IPR036971	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002073 InterPro:IPR036971	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032958	P		Seeded From UniProt	complete
enables	GO:0008081	phosphoric diester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023088 InterPro:IPR023174	F		Seeded From UniProt	complete
enables	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032958	F		Seeded From UniProt	complete
enables	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.35	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0844	P		Seeded From UniProt	complete
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References

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