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CANFA:APOE

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Species (Taxon ID) Canis familiaris (Dog) (Canis lupus familiaris). (9615)
Gene Name(s) APOE
Protein Name(s) Apolipoprotein E

Apo-E

External Links
UniProt P18649
PIR A05310
C60940
ProteinModelPortal P18649
STRING 9615.ENSCAFP00000006888
PaxDb P18649
eggNOG NOG44867
HOGENOM HOG000034006
HOVERGEN HBG010582
InParanoid P18649
Proteomes UP000002254
GO GO:0042627
GO:0034364
GO:0034361
GO:0001540
GO:0008201
GO:0008289
GO:0006869
GO:0042157
InterPro IPR000074
Pfam PF01442

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071831

intermediate-density lipoprotein particle clearance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0071830

triglyceride-rich lipoprotein particle clearance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0042158

lipoprotein biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0034447

very-low-density lipoprotein particle clearance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0034382

chylomicron remnant clearance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0034380

high-density lipoprotein particle assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0033344

cholesterol efflux

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

P

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

C

Seeded From UniProt

complete

part_of

GO:0034363

intermediate-density lipoprotein particle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

C

Seeded From UniProt

complete

part_of

GO:0034362

low-density lipoprotein particle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

C

Seeded From UniProt

complete

part_of

GO:0034361

very-low-density lipoprotein particle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

C

Seeded From UniProt

complete

enables

GO:0050750

low-density lipoprotein particle receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

F

Seeded From UniProt

complete

enables

GO:0043395

heparan sulfate proteoglycan binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

F

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

F

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02649

F

Seeded From UniProt

complete

involved_in

GO:1900221

regulation of amyloid-beta clearance

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439008
UniProtKB:P02649

P

Seeded From UniProt

complete

enables

GO:0070326

very-low-density lipoprotein particle receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439008
UniProtKB:P02649

F

Seeded From UniProt

complete

enables

GO:0060228

phosphatidylcholine-sterol O-acyltransferase activator activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88057
PANTHER:PTN000439006
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:P06727

F

Seeded From UniProt

complete

involved_in

GO:0051000

positive regulation of nitric-oxide synthase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439008
UniProtKB:P02649

P

Seeded From UniProt

complete

enables

GO:0050750

low-density lipoprotein particle receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439008
UniProtKB:P02649

F

Seeded From UniProt

complete

involved_in

GO:0046889

positive regulation of lipid biosynthetic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0043691

reverse cholesterol transport

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:P06727

P

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439008
RGD:2138

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88057
PANTHER:PTN000439006
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:P06727
UniProtKB:Q6Q788

P

Seeded From UniProt

complete

part_of

GO:0042627

chylomicron

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
RGD:2132
RGD:2138
UniProtKB:P02649
UniProtKB:P06727
UniProtKB:Q6Q788

C

Seeded From UniProt

complete

involved_in

GO:0042159

lipoprotein catabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88057
PANTHER:PTN000439008

P

Seeded From UniProt

complete

involved_in

GO:0042157

lipoprotein metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88057
PANTHER:PTN000439006
RGD:2138

P

Seeded From UniProt

complete

involved_in

GO:0034380

high-density lipoprotein particle assembly

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
UniProtKB:P02647
UniProtKB:P02649

P

Seeded From UniProt

complete

involved_in

GO:0034372

very-low-density lipoprotein particle remodeling

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88057
PANTHER:PTN000439006
UniProtKB:P02649
UniProtKB:P06727

P

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
RGD:2130
RGD:2138
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:P06727
UniProtKB:Q6Q788

C

Seeded From UniProt

complete

part_of

GO:0034363

intermediate-density lipoprotein particle

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439008
RGD:2138
UniProtKB:P02649

C

Seeded From UniProt

complete

involved_in

GO:0033700

phospholipid efflux

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:P06727

P

Seeded From UniProt

complete

involved_in

GO:0033344

cholesterol efflux

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88049
MGI:MGI:88057
PANTHER:PTN000439006
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:P06727

P

Seeded From UniProt

complete

involved_in

GO:0032374

regulation of cholesterol transport

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
UniProtKB:P06727

P

Seeded From UniProt

complete

involved_in

GO:0019433

triglyceride catabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
UniProtKB:Q6Q788

P

Seeded From UniProt

complete

enables

GO:0017127

cholesterol transporter activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88049
MGI:MGI:88057
PANTHER:PTN000439006
RGD:2130
UniProtKB:P02647
UniProtKB:P06727

F

Seeded From UniProt

complete

enables

GO:0015485

cholesterol binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
UniProtKB:P02647

F

Seeded From UniProt

complete

involved_in

GO:0010873

positive regulation of cholesterol esterification

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88057
PANTHER:PTN000439006
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:P06727

P

Seeded From UniProt

complete

involved_in

GO:0006707

cholesterol catabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88057
PANTHER:PTN000439008

P

Seeded From UniProt

complete

involved_in

GO:0006695

cholesterol biosynthetic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88049
PANTHER:PTN000439006

P

Seeded From UniProt

complete

enables

GO:0005543

phospholipid binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439006
RGD:2138
UniProtKB:P02647
UniProtKB:P02649
UniProtKB:Q6Q788

F

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000439008
RGD:2138
UniProtKB:P02649

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000074

C

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000074

P

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000074

F

Seeded From UniProt

complete

involved_in

GO:0042157

lipoprotein metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000074

P

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0345

C

Seeded From UniProt

complete

part_of

GO:0034361

very-low-density lipoprotein particle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0850

C

Seeded From UniProt

complete

part_of

GO:0042627

chylomicron

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0162

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0445

P

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0446

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page