CANFA:APOE

Species (Taxon ID)	Canis familiaris (Dog) (Canis lupus familiaris). (9615)
Gene Name(s)	APOE
Protein Name(s)	Apolipoprotein E Apo-E
External Links
UniProt	P18649
PIR	A05310 C60940
ProteinModelPortal	P18649
STRING	9615.ENSCAFP00000006888
PaxDb	P18649
eggNOG	NOG44867
HOGENOM	HOG000034006
HOVERGEN	HBG010582
InParanoid	P18649
Proteomes	UP000002254
GO	GO:0042627 GO:0034364 GO:0034361 GO:0001540 GO:0008201 GO:0008289 GO:0006869 GO:0042157
InterPro	IPR000074
Pfam	PF01442

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071831	intermediate-density lipoprotein particle clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0071830	triglyceride-rich lipoprotein particle clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0034447	very-low-density lipoprotein particle clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0034382	chylomicron remnant clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	P	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	C	Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	C	Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	C	Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	C	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	C	Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	F	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	F	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02649	F	Seeded From UniProt	complete
involved_in	GO:1900221	regulation of amyloid-beta clearance	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	P	Seeded From UniProt	complete
enables	GO:0070326	very-low-density lipoprotein particle receptor binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	F	Seeded From UniProt	complete
enables	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	F	Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	P	Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 UniProtKB:P02649	F	Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 RGD:2138	P	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	P	Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2132 RGD:2138 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	C	Seeded From UniProt	complete
involved_in	GO:0042159	lipoprotein catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439008	P	Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 RGD:2138	P	Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649	P	Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02649 UniProtKB:P06727	P	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2130 RGD:2138 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	C	Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 RGD:2138 UniProtKB:P02649	C	Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P	Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P	Seeded From UniProt	complete
involved_in	GO:0032374	regulation of cholesterol transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P06727	P	Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:Q6Q788	P	Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 MGI:MGI:88057 PANTHER:PTN000439006 RGD:2130 UniProtKB:P02647 UniProtKB:P06727	F	Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647	F	Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P	Seeded From UniProt	complete
involved_in	GO:0006707	cholesterol catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439008	P	Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 PANTHER:PTN000439006	P	Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2138 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:Q6Q788	F	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439008 RGD:2138 UniProtKB:P02649	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	C	Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	F	Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	P	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0345	C	Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0850	C	Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0162	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CANFA:APOE

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References

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