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CANFA:AP3B1

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Species (Taxon ID) Canis familiaris (Dog) (Canis lupus familiaris). (9615)
Gene Name(s) AP3B1 (synonyms: ADTB3A)
Protein Name(s) AP-3 complex subunit beta-1

Adaptor protein complex AP-3 subunit beta-1 Adaptor-related protein complex 3 subunit beta-1 Beta-3A-adaptin Clathrin assembly protein complex 3 beta-1 large chain

External Links
UniProt Q7YRF1
EMBL AY221640
RefSeq NP_001002974.1
UniGene Cfa.169
ProteinModelPortal Q7YRF1
STRING 9615.ENSCAFP00000013540
PRIDE Q7YRF1
GeneID 403459
KEGG cfa:403459
CTD 8546
eggNOG COG5096
HOGENOM HOG000033978
HOVERGEN HBG050519
InParanoid Q7YRF1
KO K12397
NextBio 20816977
Proteomes UP000002254
GO GO:0030123
GO:0030665
GO:0005794
GO:0008089
GO:0048490
GO:0006886
Gene3D 1.25.10.10
InterPro IPR026740
IPR029394
IPR029390
IPR026739
IPR011989
IPR016024
IPR002553
PANTHER PTHR11134
Pfam PF01602
PF14796
PF14797
PIRSF PIRSF037096
SUPFAM SSF48371

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0061082

myeloid leukocyte cytokine production

PMID:12897784[1]

ECO:0000315

P

Figure 1 shows that a mutation of AP3B1 causes canine cyclic hematopoiesis, which results in reciprocal cycles of leukocyte (neutrophil and monocyte) production.

complete
CACAO 3571

Contributes to

GO:0043473

pigmentation

PMID:12897784[1]

ECO:0000315

P

Table 1 shows that a mutation of AP3B1 causes canine cyclic hematopoiesis which results in gray coat color in dogs.

complete
CACAO 3572

involved_in

GO:0048490

anterograde synaptic vesicle transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1T1

P

Seeded From UniProt

complete

involved_in

GO:0008089

anterograde axonal transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1T1

P

Seeded From UniProt

complete

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008089

C

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002553
InterPro:IPR015151

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002553
InterPro:IPR015151
InterPro:IPR026739
InterPro:IPR026740

P

Seeded From UniProt

complete

part_of

GO:0030117

membrane coat

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002553

C

Seeded From UniProt

complete

part_of

GO:0030123

AP-3 adaptor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026740

C

Seeded From UniProt

complete

part_of

GO:0030131

clathrin adaptor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015151

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0030665

clathrin-coated vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0071

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Benson, KF et al. (2003) Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat. Genet. 35 90-6 PubMed GONUTS page