CALS4:Q8R7L0

Species (Taxon ID)	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 /JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis). (273068)
Gene Name(s)	Hpt (ECO:0000313 with EMBL:AAM25533.1)
Protein Name(s)	Hypoxanthine-guanine phosphoribosyltransferase (ECO:0000313 with EMBL:AAM25533.1)
External Links
UniProt	Q8R7L0
EMBL	AE008691
RefSeq	WP_011026425.1
PDB	1R3U 1YFZ 2GEB
PDBsum	1R3U 1YFZ 2GEB
ProteinModelPortal	Q8R7L0
SMR	Q8R7L0
STRING	273068.TTE2394
EnsemblBacteria	AAM25533
KEGG	tte:TTE2394
PATRIC	23899523
eggNOG	ENOG4108UGV COG0634
HOGENOM	HOG000236520
KO	K00760
OrthoDB	EOG693GNP
BRENDA	2.4.2.8
SABIO-RK	Q8R7L0
EvolutionaryTrace	Q8R7L0
PRO	PR:Q8R7L0
Proteomes	UP000000555
GO	GO:0005737 GO:0004422 GO:0046872 GO:0006166
Gene3D	3.40.50.2020
InterPro	IPR005904 IPR000836 IPR029057
Pfam	PF00156
SUPFAM	SSF53271
TIGRFAMs	TIGR01203

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0000100	S-methylmethionine transmembrane transporter activity	PMID:17662107	ECO:0000250		UniProtKB:	F		The function and structure of this protein is to design compounds that would be effective inhibitors. "Almost all of the inhibitors available are analogues of the substrate or transition-state. The main drawback of these compounds is that there is poor differential inhibition among various HGPRTs. The reason maybe due to high structure similarity of HGPRTs from different species (especially the active site) even though there is only moderate sequence homology. The key residues in the active site are highly similar among HGPRTs (Table 1)."	complete CACAO 12083
enables	GO:0004422	hypoxanthine phosphoribosyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005904	F		Seeded From UniProt	complete
involved_in	GO:0006166	purine ribonucleoside salvage	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005904	P		Seeded From UniProt	complete
involved_in	GO:0009116	nucleoside metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000836	P		Seeded From UniProt	complete
enables	GO:0052657	guanine phosphoribosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.2.8	F		Seeded From UniProt	complete
enables	GO:0004422	hypoxanthine phosphoribosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.2.8	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006166	purine ribonucleoside salvage	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0660	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0032264	IMP salvage	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00591	P		Seeded From UniProt	complete
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References

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