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CAEEL:RHY1
Contents
| Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
| Gene Name(s) | rhy-1 (ECO:0000312 with WormBase:W07A12.7) | |
| Protein Name(s) | Regulator of hypoxia-inducible factor 1 (ECO:0000303 with PMID:16980385[1]) | |
| External Links | ||
| UniProt | Q9XVW1 | |
| EMBL | Z68320 | |
| PIR | T26256 | |
| RefSeq | NP_495954.1 | |
| UniGene | Cel.14204 | |
| ProteinModelPortal | Q9XVW1 | |
| STRING | 6239.W07A12.7 | |
| PaxDb | Q9XVW1 | |
| EnsemblMetazoa | [example_ID W07A12.7] | |
| GeneID | 174455 | |
| KEGG | cel:CELE_W07A12.7 | |
| UCSC | W07A12.7 | |
| CTD | 174455 | |
| WormBase | W07A12.7 | |
| eggNOG | KOG3700 ENOG410YD1T | |
| GeneTree | ENSGT00530000063340 | |
| HOGENOM | HOG000016226 | |
| InParanoid | Q9XVW1 | |
| OMA | HTGSEGR | |
| OrthoDB | EOG7R56X7 | |
| PhylomeDB | Q9XVW1 | |
| PRO | PR:Q9XVW1 | |
| Proteomes | UP000001940 | |
| GO | GO:0005789 GO:0016021 GO:0048471 GO:0016747 GO:1900038 GO:0001666 | |
| InterPro | IPR002656 | |
| Pfam | PF01757 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1900038 |
negative regulation of cellular response to hypoxia |
ECO:0000315 |
P |
Fig 5: Confirms that rhy-1 inhibits the expression of HIF-1 target genes in a real-time RT-PCR assay monitoring the expression levels of two endogenous mRNAs, K10H10.2 and F22B5.4. Mutation of rhy-1 significantly increased the expression of both genes. |
complete | |||||
|
involved_in |
GO:1900038 |
negative regulation of cellular response to hypoxia |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00007653 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00001851 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00001178 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001666 |
response to hypoxia |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00092617 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016747 |
transferase activity, transferring acyl groups other than amino-acyl groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Shen, C et al. (2006) The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1. Genetics 174 1205-14 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Ma, DK et al. (2012) CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Neuron 73 925-40 PubMed GONUTS page
