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CAEEL:RHY1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) rhy-1 (ECO:0000312 with WormBase:W07A12.7)
Protein Name(s) Regulator of hypoxia-inducible factor 1 (ECO:0000303 with PMID:16980385[1])
External Links
UniProt Q9XVW1
EMBL Z68320
PIR T26256
RefSeq NP_495954.1
UniGene Cel.14204
ProteinModelPortal Q9XVW1
STRING 6239.W07A12.7
PaxDb Q9XVW1
EnsemblMetazoa [example_ID W07A12.7]
GeneID 174455
KEGG cel:CELE_W07A12.7
UCSC W07A12.7
CTD 174455
WormBase W07A12.7
eggNOG KOG3700
ENOG410YD1T
GeneTree ENSGT00530000063340
HOGENOM HOG000016226
InParanoid Q9XVW1
OMA HTGSEGR
OrthoDB EOG7R56X7
PhylomeDB Q9XVW1
PRO PR:Q9XVW1
Proteomes UP000001940
GO GO:0005789
GO:0016021
GO:0048471
GO:0016747
GO:1900038
GO:0001666
InterPro IPR002656
Pfam PF01757

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001666

response to hypoxia

PMID:22405203[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00001178

P

Seeded From UniProt

GO:1900038

negative regulation of cellular response to hypoxia

PMID:16980385[1]

IMP: Inferred from Mutant Phenotype

P

Fig 5: Confirms that rhy-1 inhibits the expression of HIF-1 target genes in a real-time RT-PCR assay monitoring the expression levels of two endogenous mRNAs, K10H10.2 and F22B5.4. Mutation of rhy-1 significantly increased the expression of both genes.

complete
CACAO 4074

GO:0001666

response to hypoxia

PMID:22405203[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00001851

P

Seeded From UniProt

GO:0001666

response to hypoxia

PMID:22405203[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00007653

P

Seeded From UniProt

GO:0001666

response to hypoxia

PMID:22405203[2]

IMP: Inferred from Mutant Phenotype

WB:WBVar00092617

P

Seeded From UniProt

GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

GO:0016747

transferase activity, transferring acyl groups other than amino-acyl groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002656

F

Seeded From UniProt

GO:0048471

perinuclear region of cytoplasm

PMID:16980385[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:1900038

negative regulation of cellular response to hypoxia

PMID:16980385[1]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Shen, C et al. (2006) The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1. Genetics 174 1205-14 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Ma, DK et al. (2012) CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Neuron 73 925-40 PubMed GONUTS page