CAEEL:MDR1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	pgp-1
Protein Name(s)	Multidrug resistance protein pgp-1 P-glycoprotein A P-glycoprotein-related protein 1
External Links
UniProt	P34712
EMBL	X65054 Z77666
PIR	S27337 T23476
RefSeq	NP_502413.1
UniGene	Cel.12537
PDB	4F4C
PDBsum	4F4C
ProteinModelPortal	P34712
STRING	6239.K08E7.9
TCDB	3.A.1.201.14
PaxDb	P34712
PRIDE	P34712
EnsemblMetazoa	K08E7.9
GeneID	178215
KEGG	cel:CELE_K08E7.9
UCSC	K08E7.9
CTD	178215
WormBase	K08E7.9
eggNOG	COG1132
GeneTree	ENSGT00530000062896
InParanoid	P34712
KO	K05658
OMA	HTRSQIA
OrthoDB	EOG7Z3F4H
PhylomeDB	P34712
Reactome	REACT_183198 REACT_224834 REACT_243302 REACT_252009 REACT_259971
NextBio	900198
Proteomes	UP000001940
GO	GO:0016324 GO:0016021 GO:0005524 GO:0042626 GO:0008559 GO:0050829 GO:0045087 GO:0010038 GO:0055085
Gene3D	3.40.50.300
InterPro	IPR003593 IPR011527 IPR003439 IPR017871 IPR027417
Pfam	PF00664 PF00005
SMART	SM00382
SUPFAM	SSF52540 SSF90123
PROSITE	PS50929 PS00211 PS50893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0093002	response to nematicide	PMID:25516824^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015562	efflux transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2M3G0	F		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:9989496^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00003997	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:9989496^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00003997	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21949650^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005792)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:22634595^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:7743993^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010038	response to metal ion	PMID:8947035^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00003407 WB:WBGene00003997	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10613 EcoGene:EG11405 FB:FBgn0004513 MGI:MGI:97570 MGI:MGI:98483 PANTHER:PTN002517083 PomBase:SPBC25B2.02c PomBase:SPCC737.09c SGD:S000004916 TAIR:locus:2041434 UniProtKB:A0A1D8PKI5 UniProtKB:P21439 UniProtKB:Q03519 UniProtKB:Q9NP58 UniProtKB:Q9NP78 ZFIN:ZDB-GENE-080204-52	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10613 EcoGene:EG11405 FB:FBgn0004513 MGI:MGI:1924956 PANTHER:PTN002517083 PomBase:SPCC737.09c RGD:3817 RGD:3818 UniProtKB:Q03518 UniProtKB:Q03519 UniProtKB:Q2M3G0 UniProtKB:Q8IDT6 UniProtKB:Q9NP58 UniProtKB:Q9NP78 UniProtKB:Q9NRK6 WB:WBGene00001815	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004513 MGI:MGI:1924956 MGI:MGI:97569 MGI:MGI:97570 PANTHER:PTN002795061 RGD:3318 RGD:619930 RGD:620248 UniProtKB:P08183 UniProtKB:P21439 UniProtKB:Q2M3G0 WB:WBGene00003995	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR011527 InterPro:IPR017871 InterPro:IPR036640	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527 InterPro:IPR036640	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bygarski, EE et al. (2014) Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. Int J Parasitol Drugs Drug Resist 4 143-51 PubMed GONUTS page
↑ ^2.0 ^2.1 Mahajan-Miklos, S et al. (1999) Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96 47-56 PubMed GONUTS page
↑ Estes, KA et al. (2011) Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. PLoS Pathog. 7 e1002227 PubMed GONUTS page
↑ Winter, JF et al. (2012) Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat. Cell Biol. 14 666-76 PubMed GONUTS page
↑ Broeks, A et al. (1995) A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO J. 14 1858-66 PubMed GONUTS page
↑ Broeks, A et al. (1996) Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J. 15 6132-43 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25516824-1] Bygarski, EE et al. (2014) Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. Int J Parasitol Drugs Drug Resist 4 143-51 PubMed GONUTS page

[PMID:9989496-2] 2.0 ^2.1 Mahajan-Miklos, S et al. (1999) Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96 47-56 PubMed GONUTS page

[PMID:21949650-3] Estes, KA et al. (2011) Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. PLoS Pathog. 7 e1002227 PubMed GONUTS page

[PMID:22634595-4] Winter, JF et al. (2012) Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat. Cell Biol. 14 666-76 PubMed GONUTS page

[PMID:7743993-5] Broeks, A et al. (1995) A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO J. 14 1858-66 PubMed GONUTS page

[PMID:8947035-6] Broeks, A et al. (1996) Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J. 15 6132-43 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:MDR1

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