GONUTS has been updated to MW1.29.2. Most things seem to be working but be sure to report problems.

It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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CAEEL:MDR1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) pgp-1
Protein Name(s) Multidrug resistance protein pgp-1

P-glycoprotein A P-glycoprotein-related protein 1

External Links
UniProt P34712
EMBL X65054
Z77666
PIR S27337
T23476
RefSeq NP_502413.1
UniGene Cel.12537
PDB 4F4C
PDBsum 4F4C
ProteinModelPortal P34712
STRING 6239.K08E7.9
TCDB 3.A.1.201.14
PaxDb P34712
PRIDE P34712
EnsemblMetazoa K08E7.9
GeneID 178215
KEGG cel:CELE_K08E7.9
UCSC K08E7.9
CTD 178215
WormBase K08E7.9
eggNOG COG1132
GeneTree ENSGT00530000062896
InParanoid P34712
KO K05658
OMA HTRSQIA
OrthoDB EOG7Z3F4H
PhylomeDB P34712
Reactome REACT_183198
REACT_224834
REACT_243302
REACT_252009
REACT_259971
NextBio 900198
Proteomes UP000001940
GO GO:0016324
GO:0016021
GO:0005524
GO:0042626
GO:0008559
GO:0050829
GO:0045087
GO:0010038
GO:0055085
Gene3D 3.40.50.300
InterPro IPR003593
IPR011527
IPR003439
IPR017871
IPR027417
Pfam PF00664
PF00005
SMART SM00382
SUPFAM SSF52540
SSF90123
PROSITE PS50929
PS00211
PS50893

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003439
InterPro:IPR011527
InterPro:IPR017871

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

P

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

complete

GO:0006855

drug transmembrane transport

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.6.3.44

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003439
InterPro:IPR017871

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

P

Seeded From UniProt

complete

GO:0008559

xenobiotic-transporting ATPase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.6.3.44

F

Seeded From UniProt

complete

GO:0010038

response to metal ion

PMID:8947035[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00003407
WB:WBGene00003997

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000657188

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016324

apical plasma membrane

PMID:21949650[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016324

apical plasma membrane

PMID:22634595[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016324

apical plasma membrane

PMID:7743993[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016887

ATPase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003439
InterPro:IPR017871

F

Seeded From UniProt

complete

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

F

Seeded From UniProt

complete

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000657188

F

Seeded From UniProt

complete

GO:0042908

xenobiotic transport

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.6.3.44

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:9989496[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00003997

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:9989496[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00003997

P

Seeded From UniProt

complete

GO:0055085

transmembrane transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

P

Seeded From UniProt

complete

GO:0055085

transmembrane transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000657188

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Broeks, A et al. (1996) Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J. 15 6132-43 PubMed GONUTS page
  2. Estes, KA et al. (2011) Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. PLoS Pathog. 7 e1002227 PubMed GONUTS page
  3. Winter, JF et al. (2012) Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat. Cell Biol. 14 666-76 PubMed GONUTS page
  4. Broeks, A et al. (1995) A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO J. 14 1858-66 PubMed GONUTS page
  5. 5.0 5.1 Mahajan-Miklos, S et al. (1999) Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96 47-56 PubMed GONUTS page