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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.
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CAEEL:MDR1
Contents
| Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
| Gene Name(s) | pgp-1 | |
| Protein Name(s) | Multidrug resistance protein pgp-1
P-glycoprotein A P-glycoprotein-related protein 1 | |
| External Links | ||
| UniProt | P34712 | |
| EMBL | X65054 Z77666 | |
| PIR | S27337 T23476 | |
| RefSeq | NP_502413.1 | |
| UniGene | Cel.12537 | |
| PDB | 4F4C | |
| PDBsum | 4F4C | |
| ProteinModelPortal | P34712 | |
| STRING | 6239.K08E7.9 | |
| TCDB | 3.A.1.201.14 | |
| PaxDb | P34712 | |
| PRIDE | P34712 | |
| EnsemblMetazoa | K08E7.9 | |
| GeneID | 178215 | |
| KEGG | cel:CELE_K08E7.9 | |
| UCSC | K08E7.9 | |
| CTD | 178215 | |
| WormBase | K08E7.9 | |
| eggNOG | COG1132 | |
| GeneTree | ENSGT00530000062896 | |
| InParanoid | P34712 | |
| KO | K05658 | |
| OMA | HTRSQIA | |
| OrthoDB | EOG7Z3F4H | |
| PhylomeDB | P34712 | |
| Reactome | REACT_183198 REACT_224834 REACT_243302 REACT_252009 REACT_259971 | |
| NextBio | 900198 | |
| Proteomes | UP000001940 | |
| GO | GO:0016324 GO:0016021 GO:0005524 GO:0042626 GO:0008559 GO:0050829 GO:0045087 GO:0010038 GO:0055085 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR003593 IPR011527 IPR003439 IPR017871 IPR027417 | |
| Pfam | PF00664 PF00005 | |
| SMART | SM00382 | |
| SUPFAM | SSF52540 SSF90123 | |
| PROSITE | PS50929 PS00211 PS50893 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0006855 |
drug transmembrane transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0008559 |
xenobiotic-transporting ATPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0010038 |
response to metal ion |
IGI: Inferred from Genetic Interaction |
WB:WBGene00003407 |
P |
Seeded From UniProt |
complete | ||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0016021 |
integral component of membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0016021 |
integral component of membrane |
IBA: Inferred from Biological aspect of Ancestor |
PANTHER:PTN000657188 |
C |
Seeded From UniProt |
complete | ||
| GO:0016021 |
integral component of membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0016324 |
apical plasma membrane |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0016324 |
apical plasma membrane |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0016324 |
apical plasma membrane |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0016887 |
ATPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
IBA: Inferred from Biological aspect of Ancestor |
PANTHER:PTN000657188 |
F |
Seeded From UniProt |
complete | ||
| GO:0042908 |
xenobiotic transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0045087 |
innate immune response |
IGI: Inferred from Genetic Interaction |
WB:WBGene00003997 |
P |
Seeded From UniProt |
complete | ||
| GO:0050829 |
defense response to Gram-negative bacterium |
IGI: Inferred from Genetic Interaction |
WB:WBGene00003997 |
P |
Seeded From UniProt |
complete | ||
| GO:0055085 |
transmembrane transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0055085 |
transmembrane transport |
IBA: Inferred from Biological aspect of Ancestor |
PANTHER:PTN000657188 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Broeks, A et al. (1996) Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J. 15 6132-43 PubMed GONUTS page
- ↑ Estes, KA et al. (2011) Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. PLoS Pathog. 7 e1002227 PubMed GONUTS page
- ↑ Winter, JF et al. (2012) Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat. Cell Biol. 14 666-76 PubMed GONUTS page
- ↑ Broeks, A et al. (1995) A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO J. 14 1858-66 PubMed GONUTS page
- ↑ 5.0 5.1 Mahajan-Miklos, S et al. (1999) Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96 47-56 PubMed GONUTS page
