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CAEEL:KNL1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) knl-1
Protein Name(s) Kinetochore null protein 1
External Links
UniProt P34278
EMBL FO080288
RefSeq NP_498811.1
UniGene Cel.7545
ProteinModelPortal P34278
BioGrid 41368
DIP DIP-25115N
IntAct P34278
MINT MINT-1070626
STRING 6239.C02F5.1
PaxDb P34278
PRIDE P34278
EnsemblMetazoa C02F5.1
GeneID 176164
KEGG cel:CELE_C02F5.1
CTD 176164
WormBase C02F5.1
eggNOG NOG297213
InParanoid P34278
OMA NDTMAVF
OrthoDB EOG7NGQGT
PhylomeDB P34278
NextBio 891398
Proteomes UP000001940
GO GO:0005938
GO:0000785
GO:0005694
GO:0000940
GO:0000776
GO:0008017
GO:0032403
GO:0030953
GO:0051301
GO:0007059
GO:0045184
GO:0051382
GO:0051321
GO:0007067

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000775

chromosome, centromeric region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

GO:0000776

kinetochore

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

GO:0000776

kinetochore

PMID:14522947[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000776

kinetochore

PMID:14522947[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

GO:0000785

chromatin

PMID:16273096[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000940

condensed chromosome outer kinetochore

PMID:16273096[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:G5EDA3

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:O44956

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:O45406

F

Seeded From UniProt

complete

GO:0051382

kinetochore assembly

PMID:22331849[4]

IMP: Inferred from Mutant Phenotype

P

Knl-1 is vital for signaling and attachment of microtubules to the KMN network as seen in video 1.

complete
CACAO 3781

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:O76406

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q17635

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q21952

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q8MNT1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q95QB8

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15371340[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9N2X3

F

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

GO:0005694

chromosome

PMID:18936247[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005938

cell cortex

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0138

C

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007059

chromosome segregation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0159

P

Seeded From UniProt

complete

GO:0007059

chromosome segregation

PMID:15371340[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

complete

GO:0008017

microtubule binding

PMID:20471944[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0030953

astral microtubule organization

PMID:15767665[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032403

protein complex binding

PMID:14522947[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q17635

F

Seeded From UniProt

complete

GO:0032403

protein complex binding

PMID:14522947[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q21952

F

Seeded From UniProt

complete

GO:0045184

establishment of protein localization

PMID:18765790[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045184

establishment of protein localization

PMID:18936247[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

GO:0051301

cell division

PMID:14522947[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051321

meiotic cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

GO:0051382

kinetochore assembly

PMID:14522947[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Desai, A et al. (2003) KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 17 2421-35 PubMed GONUTS page
  2. 2.0 2.1 Monen, J et al. (2005) Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat. Cell Biol. 7 1248-55 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Cheeseman, IM et al. (2004) A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18 2255-68 PubMed GONUTS page
  4. Espeut, J et al. (2012) Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. J. Cell Biol. 196 469-82 PubMed GONUTS page
  5. 5.0 5.1 Yamamoto, TG et al. (2008) SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans. J. Cell Biol. 183 187-94 PubMed GONUTS page
  6. Welburn, JP et al. (2010) Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol. Cell 38 383-92 PubMed GONUTS page
  7. Moore, LL et al. (2005) HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans. Mol. Cell. Biol. 25 2583-92 PubMed GONUTS page
  8. Gassmann, R et al. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 22 2385-99 PubMed GONUTS page