CAEEL:KNL1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	knl-1
Protein Name(s)	Kinetochore null protein 1
External Links
UniProt	P34278
EMBL	FO080288
RefSeq	NP_498811.1
UniGene	Cel.7545
ProteinModelPortal	P34278
BioGrid	41368
DIP	DIP-25115N
IntAct	P34278
MINT	MINT-1070626
STRING	6239.C02F5.1
PaxDb	P34278
PRIDE	P34278
EnsemblMetazoa	C02F5.1
GeneID	176164
KEGG	cel:CELE_C02F5.1
CTD	176164
WormBase	C02F5.1
eggNOG	NOG297213
InParanoid	P34278
OMA	NDTMAVF
OrthoDB	EOG7NGQGT
PhylomeDB	P34278
NextBio	891398
Proteomes	UP000001940
GO	GO:0005938 GO:0000785 GO:0005694 GO:0000940 GO:0000776 GO:0008017 GO:0032403 GO:0030953 GO:0051301 GO:0007059 GO:0045184 GO:0051382 GO:0051321 GO:0007067

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051382	kinetochore assembly	PMID:22331849^[1]	ECO:0000315			P		Knl-1 is vital for signaling and attachment of microtubules to the KMN network as seen in video 1.	complete CACAO 3781
involved_in	GO:1905342	positive regulation of protein localization to kinetochore	PMID:18765790^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903394	protein localization to kinetochore involved in kinetochore assembly	PMID:18765790^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	PMID:26119738^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:26119738^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051382	kinetochore assembly	PMID:15371340^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:18765790^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:24567362^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	exists_during:(WBls:0000102)	Seeded From UniProt	complete
involved_in	GO:1903394	protein localization to kinetochore involved in kinetochore assembly	PMID:24567362^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(WBls:0000102) has_regulation_target:(UniProtKB:Q21776) has_regulation_target:(UniProtKB:G5EFM0)	Seeded From UniProt	complete
involved_in	GO:0043060	meiotic metaphase I plate congression	PMID:20729837^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(WBbt:0006797)	Seeded From UniProt	complete
involved_in	GO:0034501	protein localization to kinetochore	PMID:20729837^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(WBbt:0006797) has_regulation_target:(UniProtKB:O76406) has_regulation_target:(UniProtKB:Q95QB8) has_regulation_target:(UniProtKB:Q17635) has_regulation_target:(UniProtKB:Q95XP9) has_regulation_target:(UniProtKB:Q21776) has_regulation_target:(UniProtKB:Q9N3R7) has_regulation_target:(UniProtKB:H2L0D9) has_regulation_target:(UniProtKB:O76447) has_regulation_target:(UniProtKB:P32744)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:20729837^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0006797)	Seeded From UniProt	complete
involved_in	GO:0051307	meiotic chromosome separation	PMID:20729837^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(WBbt:0006797)	Seeded From UniProt	complete
involved_in	GO:0000212	meiotic spindle organization	PMID:20729837^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(WBbt:0006797)	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:20471944^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:14522947^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051382	kinetochore assembly	PMID:14522947^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	PMID:14522947^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	PMID:18936247^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	PMID:18765790^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:14522947^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q21952	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:14522947^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q17635	F		Seeded From UniProt	complete
involved_in	GO:0030953	astral microtubule organization	PMID:15767665^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:15371340^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:18936247^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000940	condensed chromosome outer kinetochore	PMID:16273096^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:16273096^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:14522947^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0159	P		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Espeut, J et al. (2012) Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. J. Cell Biol. 196 469-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gassmann, R et al. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 22 2385-99 PubMed GONUTS page
↑ ^3.0 ^3.1 Espeut, J et al. (2015) Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation. Cell Rep 12 58-65 PubMed GONUTS page
↑ ^4.0 ^4.1 Cheeseman, IM et al. (2004) A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18 2255-68 PubMed GONUTS page
↑ ^5.0 ^5.1 Moyle, MW et al. (2014) A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J. Cell Biol. 204 647-57 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Dumont, J et al. (2010) A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat. Cell Biol. 12 894-901 PubMed GONUTS page
↑ Welburn, JP et al. (2010) Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol. Cell 38 383-92 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Desai, A et al. (2003) KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 17 2421-35 PubMed GONUTS page
↑ ^9.0 ^9.1 Yamamoto, TG et al. (2008) SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans. J. Cell Biol. 183 187-94 PubMed GONUTS page
↑ Moore, LL et al. (2005) HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans. Mol. Cell. Biol. 25 2583-92 PubMed GONUTS page
↑ ^11.0 ^11.1 Monen, J et al. (2005) Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat. Cell Biol. 7 1248-55 PubMed GONUTS page

[PMID:22331849-1] Espeut, J et al. (2012) Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. J. Cell Biol. 196 469-82 PubMed GONUTS page

[PMID:18765790-2] 2.0 ^2.1 ^2.2 ^2.3 Gassmann, R et al. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 22 2385-99 PubMed GONUTS page

[PMID:26119738-3] 3.0 ^3.1 Espeut, J et al. (2015) Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation. Cell Rep 12 58-65 PubMed GONUTS page

[PMID:15371340-4] 4.0 ^4.1 Cheeseman, IM et al. (2004) A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18 2255-68 PubMed GONUTS page

[PMID:24567362-5] 5.0 ^5.1 Moyle, MW et al. (2014) A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J. Cell Biol. 204 647-57 PubMed GONUTS page

[PMID:20729837-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Dumont, J et al. (2010) A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat. Cell Biol. 12 894-901 PubMed GONUTS page

[PMID:20471944-7] Welburn, JP et al. (2010) Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol. Cell 38 383-92 PubMed GONUTS page

[PMID:14522947-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Desai, A et al. (2003) KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 17 2421-35 PubMed GONUTS page

[PMID:18936247-9] 9.0 ^9.1 Yamamoto, TG et al. (2008) SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans. J. Cell Biol. 183 187-94 PubMed GONUTS page

[PMID:15767665-10] Moore, LL et al. (2005) HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans. Mol. Cell. Biol. 25 2583-92 PubMed GONUTS page

[PMID:16273096-11] 11.0 ^11.1 Monen, J et al. (2005) Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat. Cell Biol. 7 1248-55 PubMed GONUTS page

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CAEEL:KNL1

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