BUNYW:NSS

Species (Taxon ID)	Bunyamwera virus (BUNV). (35304)
Gene Name(s)	N
Protein Name(s)	Non-structural protein NS-S
External Links
UniProt	P16494
EMBL	D00353
PIR	B31365
RefSeq	NP_047214.1
GeneID	2648218
Proteomes	UP000002476
GO	GO:0039523
InterPro	IPR000797
Pfam	PF01104
PIRSF	PIRSF003954

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046725	negative regulation of viral protein levels in host cell	PMID:11209062	ECO:0000315			P		Fig 4A: BHK cells were infected with wildtype BUN, Maguari virus, or BUNdelNSs, N proteins appeared more prominently in cells infected with BUNdelNSs	complete CACAO 9701
	GO:0017148	negative regulation of translation	PMID:11209062	ECO:0000315			P		Fig 4A: BHK cells were infected with wildtype BUN, Maguari virus, or BUNdelNSs, N proteins appeared more prominently in cells infected with BUNdelNSs	complete CACAO 9702
	GO:0010629	negative regulation of gene expression	PMID:11209062	ECO:0000315			P		Fig 4A: BHK cells were infected with wildtype BUN, Maguari virus, or BUNdelNSs, N proteins appeared more prominently in cells infected with BUNdelNSs	complete CACAO 9703
	GO:0009405	pathogenesis	PMID:11209062	ECO:0000315			P		Fig. 5: mice were inoculated with wildtype or BUNdelNSs, mice inoculated with BUNdelNSs took longer to die than mice inoculated with wildtype	complete CACAO 9704
	GO:0039501	suppression by virus of host type I interferon production	PMID:11209062	ECO:0000315			P		Fig. 7A: BF cells were infected with wildtype or mutant virus, wildtype virus resulted in decreased luciferase activity compared to mutant (luciferase activity related to induction of IFN-beta promoter) Fig. 7B: to make sure NSs targeted IFN-beta and not just proteins in general, cells were transfected with a plasmid where luciferase expression was controlled by a different promoter, luciferase activity of the wild-type and mutant were similar and higher than luficerase activity of the wild-type in Fig. 7A	complete CACAO 9705
	GO:0039657	suppression by virus of host gene expression	PMID:11209062	ECO:0000315			P		Fig. 4B: BHK cells were infected with wildtype, and mutant. More host cells proteins were seen in cells infected by mutant than cells infected by wildtype	complete CACAO 9708
	GO:0039604	suppression by virus of host translation	PMID:11209062	ECO:0000315			P		Fig. 4B: BHK cells were infected with wildtype or BUNdelNSs, more host cell proteins were seen in cells infected with mutant than cells infected with wildtype	complete CACAO 9710
	GO:0039653	suppression by virus of host transcription	PMID:11209062	ECO:0000315			P		Fig. 4B: BHK cells were infected with wildtype, and mutant. More host cells proteins were seen in cells infected by mutant than cells infected by wildtype	complete CACAO 9711
	GO:0019080	viral gene expression	PMID:11209062	ECO:0000315			P		Fig 4A: BHK cells were infected with wildtype BUN, Maguari virus, or BUNdelNSs, N proteins appeared more prominently in cells infected with BUNdelNSs	complete CACAO 9713
	GO:0019081	viral translation	PMID:11209062	ECO:0000315			P		Fig 4A: BHK cells were infected with wildtype BUN, Maguari virus, or BUNdelNSs, N proteins appeared more prominently in cells infected with BUNdelNSs	complete CACAO 9714
	GO:0019083	viral transcription	PMID:11209062	ECO:0000315			P		Fig 4A: BHK cells were infected with wildtype BUN, Maguari virus, or BUNdelNSs, N proteins appeared more prominently in cells infected with BUNdelNSs	complete CACAO 9718
	GO:0039523	suppression by virus of host RNA polymerase II activity	PMID:15150262	ECO:0000315			P		Fig. 2: wildtype reduced phosphorylation of serine 2 in RNA polymerase II, mutant didn't Fig. 3: phosphorylated serine 2 and phosphorylated serine 5 were not very noticeable in cells expressing NSs CTD phosphorylation affects RNA polymerase II regulation	complete CACAO 9888
	GO:0039501	suppression by virus of host type I interferon production	PMID:15150262	ECO:0000314			P		Fig. 1A: cells were transfected with IFN-beta promoter-luciferase plasmids and NSs expression plasmids, cells expressing NSs had lower levels of IFN-beta promoter activation than cells expressing control protein	complete CACAO 9893
	GO:0039584	suppression by virus of host protein kinase activity	PMID:15150262	ECO:0000314			P		Fig. 1A: cells were transfected with thymidine kinase promoter-luciferase reporter plasmids and NSs expression plasmids, cells expressing Ns had lower levels of thymidine kinase promoter activity than cells expressing control protein	complete CACAO 9894
involved_in	GO:0039501	suppression by virus of host type I interferon production	PMID:15150262	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	PMID:15150262	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019080	viral gene expression	PMID:11209062	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	PMID:11209062	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0039501	suppression by virus of host type I interferon production	PMID:11209062	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	PMID:11209062	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046725	negative regulation by virus of viral protein levels in host cell	PMID:11209062	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000797	P		Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1104	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P		Seeded From UniProt	complete
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