BPT7:PRIM

Species (Taxon ID)	Enterobacteria phage T7 (Bacteriophage T7). (10760)
Gene Name(s)	No Information Provided.
Protein Name(s)	DNA primase/helicase Gene product 4 Gp4
External Links
UniProt	P03692
EMBL	V01127 V01146 V01146
PIR	A04314
RefSeq	NP_041975.1 NP_041977.1
PDB	1CR0 1CR1 1CR2 1CR4 1E0J 1E0K 1NUI 1Q57
PDBsum	1CR0 1CR1 1CR2 1CR4 1E0J 1E0K 1NUI 1Q57
ProteinModelPortal	P03692
SMR	P03692
IntAct	P03692
MINT	MINT-1513747
GeneID	1261046 1261048
KEGG	vg:1261046 vg:1261048
KO	K17680
EvolutionaryTrace	P03692
Proteomes	UP000000840
GO	GO:0043139 GO:0005524 GO:0003896 GO:0003697 GO:0008270
Gene3D	3.40.50.300
InterPro	IPR007694 IPR027417 IPR013237 IPR006171 IPR027032
PANTHER	PTHR12873
Pfam	PF03796 PF08273
SMART	SM00778 SM00493
SUPFAM	SSF52540
PROSITE	PS51199 PS50880

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003678	P		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007694	F		Seeded From UniProt	complete
	GO:0003896	DNA primase activity	PMID:11279245	ECO:0000314			F		Figs. 5, 6. "An altered gene 4 protein that does not form functional hexamers and consequently lacks detectable DNA unwinding activity was created. Remarkably, this monomeric primase readily primes DNA synthesis by T7 DNA polymerase on single-stranded templates. The monomeric gene 4 protein forms a specific and stable complex with T7 DNA polymerase and thereby delivers the RNA primer to the polymerase for the onset of DNA synthesis. These results show that a single subunit of the primase-helicase hexamer contains all of the residues required for primer synthesis and for utilization of primers by T7 DNA polymerase."	complete CACAO 11625
enables	GO:0003896	DNA primase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013237	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013237	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007694	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007694	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013237	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006269	DNA replication, synthesis of RNA primer	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0639	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0240	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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References

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