GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

BPT4:VR1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Enterobacteria phage T4 (Bacteriophage T4). (10665)
Gene Name(s) rI (synonyms: 58.6, rIA, tk.-2)
Protein Name(s) Protein rI
External Links
UniProt P13304
EMBL X04567
U76612
AF158101
RefSeq NP_049717.1
GeneID 1258591
ProtClustDB CLSP988076
GO GO:0044229

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001899

negative regulation of cytolysis by symbiont of host cells

PMID:14527655[1]

ECO:0000315

P

Figure 1. Shows loss of rI function results in earlier lysis of host cells.

NOTE: this GO-term is not completely accurate. A new GO-term has been requested. While "GO:1901218 - negative regulation of holin activity" already exists, and is accurate to the function of this protein, this paper does not specifically show it is interacting with a holin. This paper only shows rI negatively regulates cytolysis of its host.

NTR: negative regulation of cytolysis by virus of host cells

complete
CACAO 10411

GO:0001899

negative regulation of cytolysis by symbiont of host cells

PMID:17693511[2]

ECO:0000315

P

Figure 3. Shows loss of rI function results in earlier lysis of host cells.

NOTE: this GO-term is not completely accurate. A new GO-term has been requested. While "GO:1901218 - negative regulation of holin activity" already exists, and is accurate to the function of this protein, this paper does not specifically show it is interacting with a holin. This paper only shows rI negatively regulates cytolysis of its host.

NTR: negative regulation of cytolysis by virus of host cells

complete
CACAO 10414

GO:0001899

negative regulation of cytolysis by symbiont of host cells

PMID:11361346[3]

ECO:0000315

P

Figure 4. shows loss in the function of rI results in an earlier lysis of cell.

NOTE - Go - Term requested.

NTR: negative regulation of cytolysis by virus of host cells

complete
CACAO 10423

involved_in

GO:1901218

negative regulation of holin activity

PMID:11361346[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

PMID:17693511[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901218

negative regulation of holin activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034696

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413060

C

Seeded From UniProt

complete

involved_in

GO:1901218

negative regulation of holin activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413060

P

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413060

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0019835

cytolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0204

P

Seeded From UniProt

complete

part_of

GO:0033644

host cell membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1032
UniProtKB-KW:KW-1030
UniProtKB-SubCell:SL-0373

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Los, M et al. (2003) A role for bacteriophage T4 rI gene function in the control of phage development during pseudolysogeny and in slowly growing host cells. Res. Microbiol. 154 547-52 PubMed GONUTS page
  2. 2.0 2.1 Tran, TA et al. (2007) The T4 RI antiholin has an N-terminal signal anchor release domain that targets it for degradation by DegP. J. Bacteriol. 189 7618-25 PubMed GONUTS page
  3. 3.0 3.1 Ramanculov, E & Young, R (2001) Functional analysis of the phage T4 holin in a lambda context. Mol. Genet. Genomics 265 345-53 PubMed GONUTS page