BPT4:DPOL

Species (Taxon ID)	Enterobacteria phage T4 (Bacteriophage T4). (10665)
Gene Name(s)	43
Protein Name(s)	DNA polymerase Gp43
External Links
UniProt	P04415
EMBL	M10160 X00769 AF158101 M37159
PIR	JS0791
RefSeq	NP_049662.1
PDB	1NOY 1NOZ
PDBsum	1NOY 1NOZ
ProteinModelPortal	P04415
SMR	P04415
BindingDB	P04415
ChEMBL	CHEMBL5946
GeneID	1258685
KEGG	vg:1258685
KO	K18942
BRENDA	2.7.7.7
SABIO-RK	P04415
EvolutionaryTrace	P04415
Proteomes	UP000009087
GO	GO:0008408 GO:0003677 GO:0003887 GO:0000166 GO:0039686
Gene3D	3.30.420.10 3.90.1600.10
InterPro	IPR006172 IPR017964 IPR006133 IPR006134 IPR023211 IPR012337
Pfam	PF00136 PF03104
PRINTS	PR00106
SMART	SM00486
SUPFAM	SSF53098
PROSITE	PS00116

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008408	3'-5' exonuclease activity	PMID:15037066^[1]	ECO:0000315			F	Figure 4 and Figure 5 show that the mutant phenotype of T4 that is lacking exonuclease has altered DNA polymerase activity. The wild type T4 used the proof reading exonuclease to stop at lesions in the DNA, whereas the mutant phentotype DNA polymerase bypassed the lesions due to lack of exonuclease.	complete CACAO 11937
enables	GO:0003887	DNA-directed DNA polymerase activity	PMID:1332748^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	PMID:8262948^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0039686	bidirectional double-stranded viral DNA replication	PMID:6971292^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003887	P	Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003887	P	Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003887	P	Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003887	P	Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003887	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008408	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008408	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008408	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004527	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006134 InterPro:IPR006172 InterPro:IPR017964	F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006172 InterPro:IPR017964 InterPro:IPR036397	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006134 InterPro:IPR034749	F	Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006172 InterPro:IPR017964 InterPro:IPR034749	F	Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034749	F	Seeded From UniProt	complete
involved_in	GO:0039693	viral DNA genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034749	P	Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.7	F	Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000351419	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000351419	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000351419	F	Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000351419	F	Seeded From UniProt	complete
involved_in	GO:0039686	bidirectional double-stranded viral DNA replication	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000351419	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F	Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F	Seeded From UniProt	complete
enables	GO:0003887	DNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0239	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt	complete
involved_in	GO:0039693	viral DNA genome replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1194	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tanguy Le Gac, N et al. (2004) Inactivation of the 3'-5' exonuclease of the replicative T4 DNA polymerase allows translesion DNA synthesis at an abasic site. J. Mol. Biol. 336 1023-34 PubMed GONUTS page
↑ Capson, TL et al. (1992) Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4. Biochemistry 31 10984-94 PubMed GONUTS page
↑ Reha-Krantz, LJ & Nonay, RL (1993) Genetic and biochemical studies of bacteriophage T4 DNA polymerase 3'-->5'-exonuclease activity. J. Biol. Chem. 268 27100-8 PubMed GONUTS page
↑ Huang, CC et al. (1981) Two types of replication proteins increase the rate at which T4 DNA polymerase traverses the helical regions in a single-stranded DNA template. J. Biol. Chem. 256 4087-94 PubMed GONUTS page

[PMID:15037066-1] Tanguy Le Gac, N et al. (2004) Inactivation of the 3'-5' exonuclease of the replicative T4 DNA polymerase allows translesion DNA synthesis at an abasic site. J. Mol. Biol. 336 1023-34 PubMed GONUTS page

[PMID:1332748-2] Capson, TL et al. (1992) Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4. Biochemistry 31 10984-94 PubMed GONUTS page

[PMID:8262948-3] Reha-Krantz, LJ & Nonay, RL (1993) Genetic and biochemical studies of bacteriophage T4 DNA polymerase 3'-->5'-exonuclease activity. J. Biol. Chem. 268 27100-8 PubMed GONUTS page

[PMID:6971292-4] Huang, CC et al. (1981) Two types of replication proteins increase the rate at which T4 DNA polymerase traverses the helical regions in a single-stranded DNA template. J. Biol. Chem. 256 4087-94 PubMed GONUTS page

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BPT4:DPOL

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Annotations

Notes

References

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