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BPT4:DMA

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Species (Taxon ID) Enterobacteria phage T4 (Bacteriophage T4). (10665)
Gene Name(s) DAM
Protein Name(s) DNA adenine methylase

DNA-(N(6)-adenine)-methyltransferase (ECO:0000303 with PMID:12501249[1]) Deoxyadenosyl-methyltransferase M.EcoT4Dam

External Links
UniProt P04392
EMBL X01416
X17641
K03113
AF158101
PIR A00554
RefSeq NP_049647.1
PDB 1Q0S
1Q0T
1YF3
1YFJ
1YFL
PDBsum 1Q0S
1Q0T
1YF3
1YFJ
1YFL
ProteinModelPortal P04392
SMR P04392
REBASE 2837
GeneID 1258548
KEGG vg:1258548
KO K06223
BRENDA 2.1.1.72
EvolutionaryTrace P04392
Proteomes UP000009087
GO GO:0003676
GO:0009007
GO:0006260
GO:0016032
Gene3D 1.10.1020.10
3.40.50.150
InterPro IPR023095
IPR002052
IPR012263
IPR012327
IPR029063
Pfam PF02086
PIRSF PIRSF000398
PRINTS PR00505
SUPFAM SSF53335
TIGRFAMs TIGR00571
PROSITE PS00092

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009008

DNA-methyltransferase activity

PMID:7782299[2]

ECO:0000314

F

Bacteriophage T4 dam gene expressed in plasmid by direct assay by authors. Fig 6

complete
CACAO 11903

GO:0032259

methylation

PMID:2510127[3]

ECO:0000315

P

Table 1 shows that the mutant phenotype of T4 with a different amino acid at residue 126 had higher methylation rates of different amino acids, due to relaxation in sequence specificity caused by the mutation.

complete
CACAO 11912

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002052

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002052

F

Seeded From UniProt

complete

enables

GO:0009007

site-specific DNA-methyltransferase (adenine-specific) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012263
InterPro:IPR012327
InterPro:IPR023095

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002052

P

Seeded From UniProt

complete

involved_in

GO:0032775

DNA methylation on adenine

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012263
InterPro:IPR012327

P

Seeded From UniProt

complete

enables

GO:0009007

site-specific DNA-methyltransferase (adenine-specific) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.72

F

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0099018

restriction-modification system evasion by virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1258

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Zinoviev, VV et al. (2003) Bacteriophage T4 Dam DNA-(N6-adenine)-methyltransferase. Processivity and orientation to the methylation target. J. Biol. Chem. 278 7829-33 PubMed GONUTS page
  2. Kossykh, VG et al. (1995) Phage T4 DNA [N6-adenine]methyltransferase. Overexpression, purification, and characterization. J. Biol. Chem. 270 14389-93 PubMed GONUTS page
  3. Miner, Z et al. (1989) Single amino acid changes that alter the DNA sequence specificity of the DNA-[N6-adenine] methyltransferase (Dam) of bacteriophage T4. Nucleic Acids Res. 17 8149-57 PubMed GONUTS page