BPT4:A0A023ZV65

Species (Taxon ID)	Enterobacteria phage T4 (Bacteriophage T4). (10665)
Gene Name(s)	segB (ECO:0000313 with EMBL:AHY83542.1)
Protein Name(s)	Homing endonuclease (ECO:0000313 with EMBL:AHY83542.1)
External Links
UniProt	A0A023ZV65
EMBL	HM137666 KJ477684 KJ477685 KJ477686
RefSeq	NP_049745.2
GeneID	1258659
KEGG	vg:1258659
OrthoDB	VOG090000QM
Proteomes	UP000001092 UP000185269 UP000185270 UP000185271
GO	GO:0004519
Gene3D	3.40.1440.10
InterPro	IPR000305 IPR035901
Pfam	PF01541
SMART	SM00465
SUPFAM	SSF82771
PROSITE	PS50164

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004519	endonuclease activity	PMID:18281701	ECO:0000247			F		Bacteriophage T4 segB gene encodes for a protein of unknown function, but is homologous to homing endonucleases of the GIY-YIG family. By using sequence alignment with PCR, the study demonstrates that the SegB protein is a site-specific endonuclease, by analyszing the DNA cleavage site. The cleavage site analysis suggests SegB is a homing endonuclease that functions to spread its own gene among T4-related phages. In Figure 3, it is shown that Phage T4 SegB protein demonstrates endonuclease activity by cleaving DNA in the presence of Mg2+, Mn2+ or Ca2+ cations. Although the study uses a wet lab, the focus is on sequencing; the evidence is sequence alignment, instead of direct assay.	Missing: with/from CACAO 13299
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.