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BPQBE:D0U1G3
Contents
| Species (Taxon ID) | Enterobacteria phage Qbeta (Bacteriophage Q-beta). (39803) | |
| Gene Name(s) | A2 (ECO:0000313 with EMBL:AEQ25540.1) | |
| Protein Name(s) | A2 maturation protein (ECO:0000313 with EMBL:ACY07234.1)
Maturation protein (ECO:0000313 with EMBL:AEQ25540.1) | |
| External Links | ||
| UniProt | D0U1G3 | |
| EMBL | GQ153931 JF719735 | |
| GO | GO:0046718 | |
| InterPro | IPR005563 | |
| Pfam | PF03863 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0039635 |
suppression by virus of host peptidoglycan biosynthetic process |
ECO:0000314 |
P |
Fig 2 – A2 expression inhibits [3H]-DAP incorporation into the cell wall, causes degradation of cell wall (black circle = A2 expression, clear circle = no A2 expression) Suggests that A2 inhibits cell wall biosynthesis – DAP is an amino acid unique to the bacterial cell wall Used this particular Uniprot ID because it's the oldest entry - there are several entries for phage Qb A2 originating from differing strains, but the exact strain was not mentioned in the paper and no one in the lab knows (paper came out of Dr. Young's lab) |
complete | |||||
| GO:0039640 |
cytolysis by virus via suppression of host peptidoglycan biosynthetic process |
ECO:0000314 |
P |
A2 causes host lysis: Fig 2 – A2 expression causes decrease in cell density indicative of host cell lysis (black square = A2 expression, clear square = no E expression) A2 inhibits PG biosynthesis: Fig 2 – A2 expression inhibits [3H]-DAP incorporation into the cell wall, causes degradation of cell wall (black circle = A2 expression, clear circle = no A2 expression) Suggests that A2 inhibits cell wall biosynthesis – DAP is an amino acid unique to the bacterial cell wall Used this particular Uniprot ID because it's the oldest entry - there are several entries for phage Qb A2 originating from differing strains, but the exact strain was not mentioned in the paper and no one in the lab knows (paper came out of Dr. Young's lab) |
complete | |||||
|
involved_in |
GO:0039636 |
suppression by virus of host cell wall biogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044659 |
cytolysis by virus of host cell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039636 |
suppression by virus of host cell wall biogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039666 |
virion attachment to host cell pilus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039666 |
virion attachment to host cell pilus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098671 |
adhesion receptor-mediated virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019835 |
cytolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Bernhardt, TG et al. (2001) A protein antibiotic in the phage Qbeta virion: diversity in lysis targets. Science 292 2326-9 PubMed GONUTS page
- ↑ Cui, Z et al. (2017) Structures of Qβ virions, virus-like particles, and the Qβ-MurA complex reveal internal coat proteins and the mechanism of host lysis. Proc. Natl. Acad. Sci. U.S.A. 114 11697-11702 PubMed GONUTS page
- ↑ Karnik, S & Billeter, M (1983) The lysis function of RNA bacteriophage Qbeta is mediated by the maturation (A2) protein. EMBO J. 2 1521-6 PubMed GONUTS page
