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BPPH2:HOLIN

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Species (Taxon ID) Bacillus phage phi29 (Bacteriophage phi-29). (10756)
Gene Name(s) 14
Protein Name(s) Antiholin (ECO:0000303 with PMID:7831803[1])

Gene product 14 gp14 Lysis inhibitor 14-131 (ECO:0000303 with PMID:7831803[1]) Protein p14 Holin (ECO:0000303 with PMID:7831803[1]) Lysis protein 14-129 (ECO:0000303 with PMID:7831803[1])

External Links
UniProt P11188
EMBL M14782
X04962
EU771092
PIR A24721
RefSeq YP_002004543.1
TCDB 1.E.10.1.1
GeneID 6446519
KEGG vg:6446519
OrthoDB VOG0900014G
Proteomes UP000001207
GO GO:0020002
GO:0016021
GO:0044659
InterPro IPR006480
Pfam PF05105
TIGRFAMs TIGR01593

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0019835

cytolysis

PMID:8432697[2]

ECO:0000314

P

Organism: Bacillus subtilis-infecting phage Phi-29

Protein name in paper: 'Gene-14'

Table 1. Transformation of E. Coli with phi-29 gene-14 carrying plasmid resulted in cell death as compared to cell population growth without the plasmid. Results were measured with optical density.

complete
CACAO 12434

Contributes to

GO:0033644

host cell membrane

PMID:8432697[2]

ECO:0000314

C

Organism: Bacillus subtilis phage Phi-29

Protein name in paper: 'Gene-14'

Fig 2. Analysis of membrane and cytoplasmic/periplasmic fractions with gel electrophoresis revealed presence of protein of gene 14 in membrane fractions but not cytoplasmic/periplasmic fractions. Its presence in the membrane suggests that it's a membrane-bound protein.

complete
CACAO 12441

involved_in

GO:0044659

cytolysis by virus of host cell

PMID:8432697[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0033644

host cell membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043

C

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1032
UniProtKB-KW:KW-1030
UniProtKB-SubCell:SL-0373

C

Seeded From UniProt

complete

involved_in

GO:0019835

cytolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0204

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Tedin, K et al. (1995) Dual translational start motif evolutionarily conserved in the holin gene of Bacillus subtilis phage phi 29. Virology 206 479-84 PubMed GONUTS page
  2. 2.0 2.1 2.2 Steiner, M et al. (1993) The missing link in phage lysis of gram-positive bacteria: gene 14 of Bacillus subtilis phage phi 29 encodes the functional homolog of lambda S protein. J. Bacteriol. 175 1038-42 PubMed GONUTS page