GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
BPMT4:WHIB
Contents
| Species (Taxon ID) | Mycobacterium phage TM4 (Mycobacteriophage TM4). (88870) | |
| Gene Name(s) | whiBTM4 (synonyms: 49) | |
| Protein Name(s) | Probable transcriptional regulator WhiBTM4 | |
| External Links | ||
| UniProt | Q9ZX29 | |
| EMBL | AF068845 | |
| RefSeq | NP_569784.1 | |
| GeneID | 932296 | |
| KEGG | vg:932296 | |
| KO | K18955 | |
| Proteomes | UP000002133 | |
| GO | GO:0030430 GO:0051539 GO:0003677 GO:0046872 GO:0006355 GO:0006351 | |
| HAMAP | MF_01479 | |
| InterPro | IPR034768 IPR003482 | |
| PANTHER | PTHR38839 | |
| Pfam | PF02467 | |
| PROSITE | PS51674 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
P |
The protein WhiBTM4 from mycobacteriophage TM4 serves as a transcription regulator in bacteria such as M. smegmatis, in which it inhibits WhiB2. When WhiBTM4 was expressed in M. smegmatis, it caused the cells to lose acid-fast properties and created long, branched cells. WhiBTM4 caused these changes, in which the results were similar to a WhiB2 knockout protein (Fig. 2). When M. smegmatis contained the protein WhiBTM4, WhiB2 mRNA levels (measured using quantitative RT-PCR) greatly decreased compared to the wildtype, which only contained pSD24 (Fig. 3B). A decrease in mRNA levels suggests that the mycobacteriophage TM4 protein WhiBTM4 inhibits transcription of WhiB2 in M. smegmatis. WhiBTM4 binds only to a DNA WhiB2 promoter, which shows that transcription is regulated through DNA (Fig 6E). This is shown by the band created by the protein/DNA complex in figure 6 B-E. |
complete | |||||
|
enables |
GO:0051536 |
iron-sulfur cluster binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Rybniker, J et al. (2010) Insights into the function of the WhiB-like protein of mycobacteriophage TM4--a transcriptional inhibitor of WhiB2. Mol. Microbiol. 77 642-57 PubMed GONUTS page
