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BPML5:THYX

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Species (Taxon ID) Mycobacterium phage L5 (Mycobacteriophage L5). (31757)
Gene Name(s) 48
Protein Name(s) Probable thymidylate synthase

TS TSase Gp48

External Links
UniProt Q05259
EMBL Z18946
PIR S30993
RefSeq NP_039712.1
ProteinModelPortal Q05259
GeneID 2942957
KEGG vg:2942957
KO K03465
Proteomes UP000002123
GO GO:0050660
GO:0050797
GO:0006231
InterPro IPR003669
Pfam PF02511
SUPFAM SSF69796
TIGRFAMs TIGR02170
PROSITE PS51331

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050797

thymidylate synthase (FAD) activity

PMID:18248423[1]

ECO:0000314

F

Figure 2b-Release of oxidized FAD confirms that enzyme is a flavoprotein Figure 2c-Observed dUMP-dependent NADPH activity indicates sequential mechanism found within ThyX Figure 2d-Effect of ThyX co-substrate displays function through overlap at NADPH binding site Figure 2e-Conversion of dUMP to dTMP is observed (catalytic activity of ThyX)

complete
CACAO 11906

involved_in

GO:0006231

dTMP biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003669
InterPro:IPR036098

P

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003669
InterPro:IPR036098

F

Seeded From UniProt

complete

enables

GO:0050797

thymidylate synthase (FAD) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003669
InterPro:IPR036098

F

Seeded From UniProt

complete

enables

GO:0050797

thymidylate synthase (FAD) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.148

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

involved_in

GO:0009165

nucleotide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0545

P

Seeded From UniProt

complete

involved_in

GO:0006235

dTTP biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00575

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Bhattacharya, B et al. (2008) Cloning, characterization and expression analysis of nucleotide metabolism-related genes of mycobacteriophage L5. FEMS Microbiol. Lett. 280 64-72 PubMed GONUTS page