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BPA18:HOLI
Contents
Species (Taxon ID) | Listeria phage A118 (Bacteriophage A118). (40521) | |
Gene Name(s) | hol (synonyms: hol118) | |
Protein Name(s) | Holin | |
External Links | ||
UniProt | Q37975 | |
EMBL | X85008 X85008 AJ242593 | |
PIR | S69798 | |
RefSeq | NP_463485.1 | |
TCDB | 1.E.21.2.1 | |
GeneID | 922401 | |
KEGG | vg:922401 | |
OrthoDB | VOG090002OT | |
Proteomes | UP000002666 | |
GO | GO:0033644 GO:0016021 GO:0019835 GO:0019076 | |
InterPro | IPR009708 | |
Pfam | PF06946 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0019835 |
cytolysis |
ECO:0000315 |
P |
Holin Annotation Notes: Hol 118(83) is a naturally occurring altered portion of the Holin gene “Hol118” which affects cell lysis timings. Hol118(83) had a truncated N-Terminal (Thus a different start codon then usual) and when translated this portion showed slowed cell lysis. The figure shows decrease in optical density for the Hol118(83) mutant phenotypes. The mutant phenotypes were replaced with different start codons which allowed for an increase rate of cell lysis as compared with the wild type Hol118(83). The actual function of Hol118 in the holin polypeptide chain is to increase the rate of cell lysis so by induction the portion of the N-terminal that was missing in the Hol118(83) seemed to counteract its effects and allow for normal functioning .In conclusion Hol118(83) was a strong antiholin that was already present in the holin genome which could be why in UniProt we see both Holin and Antiholin functions. |
complete | |||||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019835 |
cytolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Vukov, N et al. (2003) Functional regulation of the Listeria monocytogenes bacteriophage A118 holin by an intragenic inhibitor lacking the first transmembrane domain. Mol. Microbiol. 48 173-86 PubMed GONUTS page