BPA18:HOLI

Species (Taxon ID)	Listeria phage A118 (Bacteriophage A118). (40521)
Gene Name(s)	hol (synonyms: hol118)
Protein Name(s)	Holin
External Links
UniProt	Q37975
EMBL	X85008 X85008 AJ242593
PIR	S69798
RefSeq	NP_463485.1
TCDB	1.E.21.2.1
GeneID	922401
KEGG	vg:922401
OrthoDB	VOG090002OT
Proteomes	UP000002666
GO	GO:0033644 GO:0016021 GO:0019835 GO:0019076
InterPro	IPR009708
Pfam	PF06946

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019835	cytolysis	PMID:12657053	ECO:0000315			P		Holin Annotation Notes: Hol 118(83) is a naturally occurring altered portion of the Holin gene “Hol118” which affects cell lysis timings. Hol118(83) had a truncated N-Terminal (Thus a different start codon then usual) and when translated this portion showed slowed cell lysis. The figure shows decrease in optical density for the Hol118(83) mutant phenotypes. The mutant phenotypes were replaced with different start codons which allowed for an increase rate of cell lysis as compared with the wild type Hol118(83). The actual function of Hol118 in the holin polypeptide chain is to increase the rate of cell lysis so by induction the portion of the N-terminal that was missing in the Hol118(83) seemed to counteract its effects and allow for normal functioning .In conclusion Hol118(83) was a strong antiholin that was already present in the holin genome which could be why in UniProt we see both Holin and Antiholin functions.	complete CACAO 12599
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043 UniProtKB-SubCell:SL-0380	C		Seeded From UniProt	complete
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References

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