BOVIN:CO1A1

Species (Taxon ID)	Bos taurus (Bovine). (9913)
Gene Name(s)	COL1A1
Protein Name(s)	Collagen alpha-1(I) chain Alpha-1 type I collagen
External Links
UniProt	P02453
EMBL	BC105184
PIR	A91193
RefSeq	NP_001029211.1
UniGene	Bt.23316
ProteinModelPortal	P02453
IntAct	P02453
PaxDb	P02453
PRIDE	P02453
Ensembl	ENSBTAT00000017420
GeneID	282187
KEGG	bta:282187
CTD	1277
eggNOG	NOG12793
GeneTree	ENSGT00770000120467
HOGENOM	HOG000085654
HOVERGEN	HBG004933
InParanoid	P02453
KO	K06236
OMA	KNCPGAQ
OrthoDB	EOG7TJ3HH
TreeFam	TF344135
Reactome	REACT_204848 REACT_207047 REACT_208597 REACT_209041 REACT_215758 REACT_215983 REACT_219098 REACT_219927 REACT_220688 REACT_222217 REACT_222620 REACT_223425 REACT_224259 REACT_226104
NextBio	20806015
PMAP-CutDB	P02453
Proteomes	UP000009136
ExpressionAtlas	P02453
GO	GO:0005584 GO:0005737 GO:0005615 GO:0005201 GO:0046872 GO:0001568 GO:0060346 GO:0060351 GO:0071230 GO:0071260 GO:0032964 GO:0030199 GO:0048706 GO:0001958 GO:0060325 GO:0001957 GO:0010812 GO:0001649 GO:0090263 GO:0030335 GO:0010718 GO:0045893 GO:0070208 GO:0034504 GO:0015031 GO:0007605 GO:0043589 GO:0034505 GO:0007601
InterPro	IPR008160 IPR000885 IPR001007
Pfam	PF01410 PF01391 PF00093
ProDom	PD002078
SMART	SM00038 SM00214
PROSITE	PS51461 PS01208 PS50184

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032302	MutSbeta complex	PMID:P02453	ECO:0000255			C	Fig 5 shows PCR products after the protein was affected by the mutated allele	Missing: with/from CACAO 5098
involved_in	GO:0043588	skin development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192	P	Seeded From UniProt	complete
involved_in	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002771192 RGD:61817	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88445 MGI:MGI:88446 MGI:MGI:88452 MGI:MGI:88453 MGI:MGI:88457 MGI:MGI:88467 PANTHER:PTN002513067	C	Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095415 MGI:MGI:2152695 MGI:MGI:2672118 MGI:MGI:88451 PANTHER:PTN002513067 WB:WBGene00001263 ZFIN:ZDB-GENE-030131-2281	P	Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002771192 RGD:61817	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 ZFIN:ZDB-GENE-030131-9102	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88452 MGI:MGI:88468 PANTHER:PTN002513067 RGD:61817 RGD:70936 RGD:727898 UniProtKB:P02452 UniProtKB:P02458 UniProtKB:P02461 UniProtKB:P08123 UniProtKB:Q9BXS0	C	Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 UniProtKB:P02452	C	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104687 MGI:MGI:2672118 MGI:MGI:88457 MGI:MGI:88467 PANTHER:PTN002513067 UniProtKB:P02461 UniProtKB:P02462 UniProtKB:P53420	F	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 UniProtKB:P02452	P	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002771192 RGD:61817	P	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 UniProtKB:P02452 ZFIN:ZDB-GENE-030131-9102	P	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0043589	skin morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	F	Seeded From UniProt	complete
involved_in	GO:0034505	tooth mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0032964	collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	C	Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	C	Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	F	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0070208	protein heterotrimerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0060351	cartilage development involved in endochondral bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0060346	bone trabecula formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	C	Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	C	Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	C	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	F	Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0001957	intramembranous ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11087 ensembl:ENSMUSP00000001547	P	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000885	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0176	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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BOVIN:CO1A1

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References

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