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BOVIN:BPT1
Contents
| Species (Taxon ID) | Bos taurus (Bovine). (9913) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Pancreatic trypsin inhibitor
Aprotinin Basic protease inhibitor BPI BPTI | |
| External Links | ||
| UniProt | P00974 | |
| EMBL | M20934 M20930 M20932 X03365 X03365 X05274 | |
| PIR | S00277 | |
| UniGene | Bt.28518 | |
| PDB | 1AAL 1B0C 1BHC 1BPI 1BPT 1BRB 1BTH 1BTI 1BZ5 1BZX 1CBW 1CO7 1D0D 1EAW 1EJM 1F5R 1F7Z 1FAK 1FAN 1FY8 1G6X 1JV8 1JV9 1K09 1K6U 1LD5 1LD6 1MTN 1NAG 1OA5 1OA6 1P2I 1P2J 1P2K 1P2M 1P2N 1P2O 1P2Q 1PIT 1QLQ 1T7C 1T8L 1T8M 1T8N 1T8O 1TPA 1UUA 1UUB 1YKT 1YLC 1YLD 2FI3 2FI4 2FI5 2FTL 2FTM 2HEX 2IJO 2KAI 2PTC 2R9P 2RA3 2TGP 2TPI 2ZJX 2ZVX 3BTD 3BTE 3BTF 3BTG 3BTH 3BTK 3BTM 3BTQ 3BTT 3BTW 3FP6 3FP7 3FP8 3GYM 3LDI 3LDJ 3LDM 3OTJ 3P92 3P95 3TGI 3TGJ 3TGK 3TPI 3U1J 3WNY 4BNR 4DG4 4PTI 4TPI 5PTI 6PTI 7PTI 8PTI 9PTI | |
| PDBsum | 1AAL 1B0C 1BHC 1BPI 1BPT 1BRB 1BTH 1BTI 1BZ5 1BZX 1CBW 1CO7 1D0D 1EAW 1EJM 1F5R 1F7Z 1FAK 1FAN 1FY8 1G6X 1JV8 1JV9 1K09 1K6U 1LD5 1LD6 1MTN 1NAG 1OA5 1OA6 1P2I 1P2J 1P2K 1P2M 1P2N 1P2O 1P2Q 1PIT 1QLQ 1T7C 1T8L 1T8M 1T8N 1T8O 1TPA 1UUA 1UUB 1YKT 1YLC 1YLD 2FI3 2FI4 2FI5 2FTL 2FTM 2HEX 2IJO 2KAI 2PTC 2R9P 2RA3 2TGP 2TPI 2ZJX 2ZVX 3BTD 3BTE 3BTF 3BTG 3BTH 3BTK 3BTM 3BTQ 3BTT 3BTW 3FP6 3FP7 3FP8 3GYM 3LDI 3LDJ 3LDM 3OTJ 3P92 3P95 3TGI 3TGJ 3TGK 3TPI 3U1J 3WNY 4BNR 4DG4 4PTI 4TPI 5PTI 6PTI 7PTI 8PTI 9PTI | |
| DisProt | DP00729 | |
| ProteinModelPortal | P00974 | |
| SMR | P00974 | |
| DIP | DIP-6113N | |
| IntAct | P00974 | |
| MINT | MINT-90698 | |
| STRING | 9913.ENSBTAP00000023042 | |
| Allergome | 3890 | |
| MEROPS | I02.001 | |
| PRIDE | P00974 | |
| eggNOG | KOG3540 | |
| HOGENOM | HOG000007327 | |
| HOVERGEN | HBG006193 | |
| EvolutionaryTrace | P00974 | |
| Proteomes | UP000009136 | |
| GO | GO:0005576 GO:0019870 GO:0004867 | |
| Gene3D | 4.10.410.10 | |
| InterPro | IPR002223 IPR020901 | |
| Pfam | PF00014 | |
| PRINTS | PR00759 | |
| SMART | SM00131 | |
| SUPFAM | SSF57362 | |
| PROSITE | PS00280 PS50279 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0070495 |
negative regulation of thrombin receptor signaling pathway |
ECO:0000314 |
P |
Fig. 4: Aprotinin inhibits the ability of thrombin to induce a fibrin clot. The fibrinogen concentration was contant at curve a while the clotting time increased from curve b to e with the presence of aprotinin |
complete | |||||
| GO:0090331 |
negative regulation of platelet aggregation |
ECO:0000314 |
P |
Fig. 5 shows the aggregation of human platelets was reduced by increasing concentration of aprotinin. Curve a was the control(without the presence of aprotinin) |
complete | |||||
|
enables |
GO:0043199 |
sulfate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097180 |
serine protease inhibitor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097180 |
serine protease inhibitor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035375 |
zymogen binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900004 |
negative regulation of serine-type endopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032023 |
trypsinogen activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090331 |
negative regulation of platelet aggregation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070495 |
negative regulation of thrombin-activated receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019870 |
potassium channel inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000008981 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002226010 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Pintigny, D & Dachary-Prigent, J (1992) Aprotinin can inhibit the proteolytic activity of thrombin. A fluorescence and an enzymatic study. Eur. J. Biochem. 207 89-95 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Kawamura, K et al. (2011) X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complex. Acta Crystallogr. D Biol. Crystallogr. 67 140-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Vincent, JP & Lazdunski, M (1976) Pre-existence of the active site in zymogens, the interaction of trypsinogen with the basic pancreatic trypsin inhibitor (Kunitz). FEBS Lett. 63 240-4 PubMed GONUTS page
- ↑ Moss, GW et al. (1996) An evolutionarily conserved binding site for serine proteinase inhibitors in large conductance calcium-activated potassium channels. Biochemistry 35 16024-35 PubMed GONUTS page
- ↑ 5.0 5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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