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BOVIN:ADA
Contents
| Species (Taxon ID) | Bos taurus (Bovine). (9913) | |
| Gene Name(s) | ADA | |
| Protein Name(s) | Adenosine deaminase
Adenosine aminohydrolase | |
| External Links | ||
| UniProt | P56658 | |
| EMBL | AF280603 | |
| RefSeq | NP_776312.1 | |
| UniGene | Bt.4303 | |
| PDB | 1KRM 1NDV 1NDW 1NDY 1NDZ 1O5R 1QXL 1UML 1V79 1V7A 1VFL 1W1I 1WXY 1WXZ 2BGN 2E1W 2Z7G | |
| PDBsum | 1KRM 1NDV 1NDW 1NDY 1NDZ 1O5R 1QXL 1UML 1V79 1V7A 1VFL 1W1I 1WXY 1WXZ 2BGN 2E1W 2Z7G | |
| ProteinModelPortal | P56658 | |
| SMR | P56658 | |
| IntAct | P56658 | |
| STRING | 9913.ENSBTAP00000006947 | |
| BindingDB | P56658 | |
| ChEMBL | CHEMBL2966 | |
| PaxDb | P56658 | |
| PRIDE | P56658 | |
| GeneID | 280712 | |
| KEGG | bta:280712 | |
| CTD | 100 | |
| eggNOG | COG1816 | |
| HOGENOM | HOG000218816 | |
| HOVERGEN | HBG001718 | |
| InParanoid | P56658 | |
| KO | K01488 | |
| BRENDA | 3.5.4.4 | |
| EvolutionaryTrace | P56658 | |
| NextBio | 20804891 | |
| PRO | PR:P56658 | |
| Proteomes | UP000009136 | |
| GO | GO:0030054 GO:0060205 GO:0005886 GO:0004000 GO:0008270 GO:0006154 GO:0007155 GO:0046103 GO:0009117 GO:0009168 | |
| HAMAP | MF_00540 | |
| InterPro | IPR006650 IPR001365 IPR028893 IPR006330 | |
| Pfam | PF00962 | |
| TIGRFAMs | TIGR01430 | |
| PROSITE | PS00485 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005488 |
binding |
ECO:0000314 |
F |
Deoxycoformycin |
complete | |||||
| GO:0004000 |
adenosine deaminase activity |
ECO:0000314 |
F |
ADA was purified and assayed for adenosine deaminase activity (Figure 1). |
complete | |||||
|
involved_in |
GO:0046103 |
inosine biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006154 |
adenosine catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004000 |
adenosine deaminase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060169 |
negative regulation of adenosine receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000150945 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046103 |
inosine biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87916 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043103 |
hypoxanthine salvage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10030 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042110 |
T cell activation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000150945 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000150945 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006154 |
adenosine catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10030 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10030 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004000 |
adenosine deaminase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10030 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004000 |
adenosine deaminase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009168 |
purine ribonucleoside monophosphate biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019239 |
deaminase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004000 |
adenosine deaminase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009117 |
nucleotide metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0060205 |
cytoplasmic vesicle lumen |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Frick, L et al. (1986) Transition-state stabilization by adenosine deaminase: structural studies of its inhibitory complex with deoxycoformycin. Biochemistry 25 1616-21 PubMed GONUTS page
- ↑ Wolfenden, R et al. (1967) Substrate binding by adenosine deaminase. Specificity, pH dependence, and competition by mercurials. J. Biol. Chem. 242 977-83 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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