BORPE:CYAA

Species (Taxon ID)	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251). (257313)
Gene Name(s)	cya (synonyms: cyaA)
Protein Name(s)	Bifunctional hemolysin/adenylate cyclase AC-HLY ACT Cyclolysin Calmodulin-sensitive adenylate cyclase ATP pyrophosphate-lyase Adenylyl cyclase Hemolysin
External Links
UniProt	P0DKX7
EMBL	BX640413
PIR	S00893
RefSeq	NP_879578.1
PDB	1YRT 1YRU 1ZOT 2COL
PDBsum	1YRT 1YRU 1ZOT 2COL
DisProt	DP00591
ProteinModelPortal	P0DKX7
SMR	P0DKX7
EnsemblBacteria	CAE41066
GeneID	2664492
KEGG	bpe:BP0760
eggNOG	COG2931
HOGENOM	HOG000112122
KO	K11005 K11029
OMA	CPLGWHS
EvolutionaryTrace	P15318
Proteomes	UP000002676
GO	GO:0005576 GO:0004016 GO:0005524 GO:0005509 GO:0008294 GO:0044179 GO:0009405 GO:0007204
Gene3D	2.150.10.10
InterPro	IPR005165 IPR018511 IPR001343 IPR018504 IPR003995 IPR011049
Pfam	PF03497 PF00353 PF02382
PRINTS	PR01488
SUPFAM	SSF51120
PROSITE	PS00330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007204	elevation of cytosolic calcium ion concentration	PMID:17148436	ECO:0000314			P		Figure 1.	complete CACAO 4613
	GO:2001170	negative regulation of ATP biosynthetic process	PMID:17148436	ECO:0000314			P		Figure 3.	complete CACAO 4617
	GO:0004016	adenylate cyclase activity	PMID:17148436	ECO:0000314			F		Table 1.	complete CACAO 4618
	GO:0044179	hemolysis in other organism	PMID:17148436	ECO:0000314			P		Table 1.	complete CACAO 4619
involved_in	GO:0044179	hemolysis in other organism	PMID:17148436	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:17148436	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004016	adenylate cyclase activity	PMID:17148436	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0007204	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001343 InterPro:IPR003995 InterPro:IPR018504	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003995 InterPro:IPR005165 InterPro:IPR018504 InterPro:IPR037017	C		Seeded From UniProt	complete
enables	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005165 InterPro:IPR037017	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003995 InterPro:IPR005165 InterPro:IPR018504 InterPro:IPR037017	P		Seeded From UniProt	complete
enables	GO:0004016	adenylate cyclase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.6.1.1	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
involved_in	GO:0006171	cAMP biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0115	P		Seeded From UniProt	complete
involved_in	GO:0044179	hemolysis in other organism	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0354	P		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.