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BORPE:CYAA

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Species (Taxon ID) Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251). (257313)
Gene Name(s) cya (synonyms: cyaA)
Protein Name(s) Bifunctional hemolysin/adenylate cyclase

AC-HLY ACT Cyclolysin Calmodulin-sensitive adenylate cyclase ATP pyrophosphate-lyase Adenylyl cyclase Hemolysin

External Links
UniProt P0DKX7
EMBL BX640413
PIR S00893
RefSeq NP_879578.1
PDB 1YRT
1YRU
1ZOT
2COL
PDBsum 1YRT
1YRU
1ZOT
2COL
DisProt DP00591
ProteinModelPortal P0DKX7
SMR P0DKX7
EnsemblBacteria CAE41066
GeneID 2664492
KEGG bpe:BP0760
eggNOG COG2931
HOGENOM HOG000112122
KO K11005
K11029
OMA CPLGWHS
EvolutionaryTrace P15318
Proteomes UP000002676
GO GO:0005576
GO:0004016
GO:0005524
GO:0005509
GO:0008294
GO:0044179
GO:0009405
GO:0007204
Gene3D 2.150.10.10
InterPro IPR005165
IPR018511
IPR001343
IPR018504
IPR003995
IPR011049
Pfam PF03497
PF00353
PF02382
PRINTS PR01488
SUPFAM SSF51120
PROSITE PS00330

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007204

elevation of cytosolic calcium ion concentration

PMID:17148436[1]

ECO:0000314

P

Figure 1.

complete
CACAO 4613

GO:2001170

negative regulation of ATP biosynthetic process

PMID:17148436[1]

ECO:0000314

P

Figure 3.

complete
CACAO 4617

GO:0004016

adenylate cyclase activity

PMID:17148436[1]

ECO:0000314

F

Table 1.

complete
CACAO 4618

GO:0044179

hemolysis in other organism

PMID:17148436[1]

ECO:0000314

P

Table 1.

complete
CACAO 4619

involved_in

GO:0044179

hemolysis in other organism

PMID:17148436[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:17148436[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004016

adenylate cyclase activity

PMID:17148436[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005623

cell

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0007204

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001343
InterPro:IPR003995
InterPro:IPR018504

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003995
InterPro:IPR005165
InterPro:IPR018504
InterPro:IPR037017

C

Seeded From UniProt

complete

enables

GO:0008294

calcium- and calmodulin-responsive adenylate cyclase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005165
InterPro:IPR037017

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003995
InterPro:IPR005165
InterPro:IPR018504
InterPro:IPR037017

P

Seeded From UniProt

complete

enables

GO:0004016

adenylate cyclase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.6.1.1

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0019835

cytolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0204

P

Seeded From UniProt

complete

involved_in

GO:0006171

cAMP biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0115

P

Seeded From UniProt

complete

involved_in

GO:0044179

hemolysis in other organism

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0354

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0090729

toxin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0800

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Fiser, R et al. (2007) Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities. J. Biol. Chem. 282 2808-20 PubMed GONUTS page