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BORPE:BVGA
Contents
| Species (Taxon ID) | Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251). (257313) | |
| Gene Name(s) | bvgA | |
| Protein Name(s) | Virulence factors putative positive transcription regulator BvgA | |
| External Links | ||
| UniProt | P0A4H2 | |
| EMBL | M25401 BX640416 | |
| PIR | B33729 | |
| RefSeq | NP_880570.1 | |
| ProteinModelPortal | P0A4H2 | |
| STRING | 257313.BP1878 | |
| EnsemblBacteria | CAE42161 | |
| GeneID | 2667058 | |
| KEGG | bpe:BP1878 | |
| PATRIC | 21157044 | |
| eggNOG | COG2197 | |
| HOGENOM | HOG000034813 | |
| KO | K07690 | |
| OMA | HILLIMY | |
| OrthoDB | EOG69GZGV | |
| BioCyc | BPER257313:BP1878-MONOMER | |
| Proteomes | UP000002676 | |
| GO | GO:0003677 GO:0003700 GO:0009405 GO:0000160 GO:0006351 | |
| Gene3D | 1.10.10.10 | |
| InterPro | IPR011006 IPR001789 IPR000792 IPR011991 | |
| Pfam | PF00196 PF00072 | |
| PRINTS | PR00038 | |
| SMART | SM00421 SM00448 | |
| SUPFAM | SSF52172 | |
| PROSITE | PS00622 PS50043 PS50110 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0001140 |
bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
ECO:0000315 |
F |
Figure 8. compares the ability of WT and mutant BvgA protein to activate transcription by binding to two promoters, in the presence of RNA Polymerase. |
complete | |||||
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Figure 2. shows that two BvgA mutants, EMS12 and EMS24, had failed to express the Bvg+ phase phenotype necessary for virulence. |
complete | |||||
| GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
P |
Fig 5 shows in vitro transcription from wild type bipA promoter with increasing concentrations of Phosphorylated BvgA. Low concentrations are sufficient to activate bipA transcription, while higher concentrations inhibit transcription. |
complete | |||||
| GO:0000156 |
two-component response regulator activity |
ECO:0000315 |
F |
Figure 5. shows that the T194M mutant had a significantly reduced rate of phosphorylation by the BvgS sensor kinase. |
complete | |||||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000160 |
phosphorelay signal transduction system |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000160 |
phosphorelay signal transduction system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Jones, AM et al. (2005) Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis. Mol. Microbiol. 58 700-13 PubMed GONUTS page
- ↑ Williams, CL et al. (2005) BvgA functions as both an activator and a repressor to control Bvg phase expression of bipA in Bordetella pertussis. Mol. Microbiol. 56 175-88 PubMed GONUTS page
