GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
BORBU:O50835
Contents
| Species (Taxon ID) | Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM4680). (224326) | |
| Gene Name(s) | bbk32 (ECO:0000313 with EMBL:AAC66134.1) | |
| Protein Name(s) | Fibronectin-binding protein BBK32 (ECO:0000313 with EMBL:AAC66134.1) | |
| External Links | ||
| UniProt | O50835 | |
| EMBL | AE000788 | |
| PIR | A70255 | |
| RefSeq | NP_045605.1 WP_010258321.1 | |
| PDB | 4PZ5 | |
| PDBsum | 4PZ5 | |
| DisProt | DP01047 | |
| SMR | O50835 | |
| PRIDE | O50835 | |
| EnsemblBacteria | AAC66134 | |
| GeneID | 1194219 | |
| KEGG | bbu:BB_K32 | |
| PATRIC | fig|224326.49.peg.1452 | |
| OMA | QMYSTRL | |
| Proteomes | UP000001807 | |
| GO | GO:0001968 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0001968 |
fibronectin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0001968 |
fibronectin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
||||
| GO:0045959 |
negative regulation of complement activation, classical pathway |
ECO:0000279 |
P |
Fig. 7A-D BBK32 from Borrelia burgdorferi is shown to inhibit autocatalysis of C1r and subsequent C1r cleavage of C1s within the C1 complex. |
complete | |||||
| GO:0048519 |
negative regulation of biological process |
ECO:0001258 |
P |
Figure 4A-C shows use of classical pathway (CP)-mediated hemolysis assays using absorbance to measure cell lysis. Performed with BBK32 N-terminal, C-termainl, and full-length protein Waiting on new GO term Borrelia burgdorferi |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kim, JH et al. (2004) BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding. J. Biol. Chem. 279 41706-14 PubMed GONUTS page
- ↑ 2.0 2.1 Garcia, BL et al. (2016) Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLoS Pathog. 12 e1005404 PubMed GONUTS page
