BACSU:MCSB

Species (Taxon ID)	Bacillus subtilis (strain 168). (224308)
Gene Name(s)	mcsB (ECO:0000255 with HAMAP-Rule:MF_00602) (synonyms: yacI)
Protein Name(s)	Protein-arginine kinase (ECO:0000255 with HAMAP-Rule:MF_00602)
External Links
UniProt	P37570
EMBL	D26185 AL009126 U02604
PIR	S66114
RefSeq	NP_387966.1 WP_003235007.1
ProteinModelPortal	P37570
SMR	P37570
IntAct	P37570
MINT	MINT-4789055
STRING	224308.Bsubs1_010100000440
PaxDb	P37570
EnsemblBacteria	CAB11861
GeneID	936939
KEGG	bsu:BSU00850
PATRIC	18971675
eggNOG	ENOG41066A3 COG3869
HOGENOM	HOG000082112
InParanoid	P37570
KO	K19405
OMA	IIMQERV
OrthoDB	EOG6NKR1D
PhylomeDB	P37570
BioCyc	BSUB:BSU00850-MONOMER
Proteomes	UP000001570
GO	GO:0005737 GO:0005524 GO:0016775 GO:0004672
Gene3D	3.30.590.10
HAMAP	MF_00602
InterPro	IPR023660 IPR000749 IPR022415 IPR022414 IPR014746
PANTHER	PTHR11547
Pfam	PF00217
PROSITE	PS00112 PS51510

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006508	proteolysis	PMID:11179229	ECO:0000315			P		McsB play a role in regulating transcription of CtsR-dependent heat shock genes. Figure 5- In the mcsB mutants, CtsR-dependent heat shock proteins under non-stressed conditions were increased when compared with the wild-type. McsB influences the CtsR-mediated repression negatively. Figure 6B- The half-life of the CtsR repressor was increased in McsB mutants, suggesting that McsB destabilizes CtsR.	complete CACAO 11545
enables	GO:0016301	kinase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88407 MGI:MGI:88413 PANTHER:PTN000167125 RGD:2358 RGD:61976 UniProtKB:P00565 UniProtKB:P05122	F		Seeded From UniProt	complete
	GO:0006508	proteolysis	PMID:11179229	ECO:0000314			P		Through gel mobility shift experiments (Figure 6, lanes 8-10), it was shown that addition of McsB to CtsR led to a decrease in the amount of DNA retarded by CtsR. This suests that McsB can remove the DNA binding capacity of CtsR.	complete CACAO 11546
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004672	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014746	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022414 InterPro:IPR022415	F		Seeded From UniProt	complete
enables	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000749 InterPro:IPR022414 InterPro:IPR022415	F		Seeded From UniProt	complete
enables	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023660	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000098157	F		Seeded From UniProt	complete
enables	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000098157	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
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References

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