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BACSU:CTAA

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Species (Taxon ID) Bacillus subtilis (strain 168). (224308)
Gene Name(s) ctaA
Protein Name(s) Heme A synthase

HAS Cytochrome aa3-controlling protein

External Links
UniProt P12946
EMBL M23915
Z98682
AL009126
PIR A33960
RefSeq NP_389370.1
WP_003245869.1
ProteinModelPortal P12946
IntAct P12946
STRING 224308.BSU14870
TCDB 3.D.4.4.1
PaxDb P12946
DNASU 937030
EnsemblBacteria CAB13360
GeneID 937030
KEGG bsu:BSU14870
PATRIC 18974773
GenoList BSU14870
eggNOG COG1612
HOGENOM HOG000034527
InParanoid P12946
KO K02259
OMA AVVWGQS
OrthoDB EOG6JDWDQ
PhylomeDB P12946
BioCyc BSUB:BSU14870-MONOMER
UniPathway UPA00269
Proteomes UP000001570
GO GO:0016021
GO:0005886
GO:0016627
GO:0006784
GO:0030435
HAMAP MF_01664
InterPro IPR003780
IPR023755
Pfam PF02628

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006784

heme a biosynthetic process

PMID:7961419[1]

ECO:0000316

P

Table 2:production of cytochrome b-CTA requires both ctaA and ctaB and suggest that these genes is the structural gene for this sytochrome, which correlates with the synthesis of heme A.

Missing: with/from

GO:0004497

monooxygenase activity

PMID:12206660[2]

ECO:0000269

F

Scheme 3. "The first step produces the alcohol intermediate, while the second step forms the corresponding geminal diol. Spontaneous dehydration of the diol leads to heme A, while the overoxidized carboxylate byproduct arises from a third reaction. This process shows CtaA oxidizes heme O to heme A via monooxygenase reaction.

complete

involved_in

GO:0006784

heme a biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002177557
UniProtKB:P12946

P

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002177557
UniProtKB:P12946

F

Seeded From UniProt

complete

involved_in

GO:0006784

heme a biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003780
InterPro:IPR023755

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR023755

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003780

C

Seeded From UniProt

complete

enables

GO:0016627

oxidoreductase activity, acting on the CH-CH group of donors

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003780
InterPro:IPR023755

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003780
InterPro:IPR023755

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083309

C

Seeded From UniProt

complete

involved_in

GO:0006784

heme a biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083309

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0030435

sporulation resulting in formation of a cellular spore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0749

P

Seeded From UniProt

complete

involved_in

GO:0006783

heme biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0350

P

Seeded From UniProt

complete

involved_in

GO:0006784

heme a biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00269

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Svensson, B & Hederstedt, L (1994) Bacillus subtilis CtaA is a heme-containing membrane protein involved in heme A biosynthesis. J. Bacteriol. 176 6663-71 PubMed GONUTS page
  2. Brown, KR et al. (2002) Identification of novel hemes generated by heme A synthase: evidence for two successive monooxygenase reactions. Biochemistry 41 10906-13 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page