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ARATH:MKP1

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) MKP1
Protein Name(s) Protein-tyrosine-phosphatase MKP1

Mitogen-activated protein kinase phosphatase 1 AtMKP1

External Links
UniProt Q9C5S1
EMBL AF312745
AL132954
CP002686
AY054509
PIR T47666
RefSeq NP_567018.4
UniGene At.21664
ProteinModelPortal Q9C5S1
SMR Q9C5S1
PRIDE Q9C5S1
EnsemblPlants AT3G55270.1
GeneID 824693
KEGG ath:AT3G55270
TAIR AT3G55270
InParanoid Q9C5S1
OMA TEHETHL
PhylomeDB Q9C5S1
BioCyc ARA:AT3G55270-MONOMER
Proteomes UP000006548
ExpressionAtlas Q9C5S1
Genevestigator Q9C5S1
GO GO:0005829
GO:0017017
GO:0004725
GO:0008138
GO:0006952
GO:0000188
GO:0006470
GO:0009651
GO:0010224
GO:0010225
Gene3D 3.40.20.10
3.90.190.10
InterPro IPR029006
IPR000340
IPR020422
IPR024950
IPR029021
IPR000387
IPR016130
PANTHER PTHR10159
Pfam PF00782
SMART SM00195
SUPFAM SSF52799
PROSITE PS00383
PS50056
PS50054

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1902065

response to L-glutamate

PMID:29344832[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017017

MAP kinase tyrosine/serine/threonine phosphatase activity

PMID:21790814[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0017017

MAP kinase tyrosine/serine/threonine phosphatase activity

PMID:12456655[3]

ECO:0000250

sequence similarity evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0010225

response to UV-C

PMID:11274055[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010224

response to UV-B

PMID:21790814[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009651

response to salt stress

PMID:12456655[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21166475[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000188

inactivation of MAPK activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0017017

P

Seeded From UniProt

complete

involved_in

GO:0000188

inactivation of MAPK activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0017017

P

Seeded From UniProt

complete

GO:0052258

negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction

PMID:21447069[6]

ECO:0000315

P

Figure 2: Plants with mkp1 die when introduced to PAMP elf 26, while WT do not exude the same phenotype. When not treated with PAMP elf 26, all plants display the normal phenotype

complete
CACAO 9876

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016130

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020422

P

Seeded From UniProt

complete

enables

GO:0008138

protein tyrosine/serine/threonine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000340
InterPro:IPR020422

F

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000340
InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0611

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. López-Bucio, JS et al. (2018) Mitogen activated protein kinase 6 and MAP kinase phosphatase 1 are involved in the response of Arabidopsis roots to L-glutamate. Plant Mol. Biol. 96 339-351 PubMed GONUTS page
  2. 2.0 2.1 González Besteiro, MA et al. (2011) Arabidopsis MAP kinase phosphatase 1 and its target MAP kinases 3 and 6 antagonistically determine UV-B stress tolerance, independent of the UVR8 photoreceptor pathway. Plant J. 68 727-37 PubMed GONUTS page
  3. 3.0 3.1 Ulm, R et al. (2002) Distinct regulation of salinity and genotoxic stress responses by Arabidopsis MAP kinase phosphatase 1. EMBO J. 21 6483-93 PubMed GONUTS page
  4. Ulm, R et al. (2001) Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis. Genes Dev. 15 699-709 PubMed GONUTS page
  5. Ito, J et al. (2011) Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J. Proteome Res. 10 1571-82 PubMed GONUTS page
  6. Anderson, JC et al. (2011) Arabidopsis MAP Kinase Phosphatase 1 (AtMKP1) negatively regulates MPK6-mediated PAMP responses and resistance against bacteria. Plant J. 67 258-68 PubMed GONUTS page