ARATH:CNX1

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	CNX1
Protein Name(s)	Molybdopterin biosynthesis protein CNX1 Molybdenum cofactor biosynthesis enzyme CNX1 Molybdopterin molybdenumtransferase MPT Mo-transferase Domain E Molybdopterin adenylyltransferase MPT adenylyltransferase Domain G
External Links
UniProt	Q39054
EMBL	L47323 AJ236870 AC069325 AF296834 CP002688
RefSeq	NP_197599.1
UniGene	At.23035
PDB	1EAV 1O8N 1O8O 1O8Q 1UUX 1UUY
PDBsum	1EAV 1O8N 1O8O 1O8Q 1UUX 1UUY
ProteinModelPortal	Q39054
SMR	Q39054
BioGrid	17499
MINT	MINT-8070811
PaxDb	Q39054
PRIDE	Q39054
EnsemblPlants	AT5G20990.1
GeneID	832224
KEGG	ath:AT5G20990
TAIR	AT5G20990
eggNOG	COG0303
HOGENOM	HOG000280651
InParanoid	Q39054
KO	K15376
OMA	KITPFAM
PhylomeDB	Q39054
Reactome	REACT_187830
UniPathway	UPA00344
EvolutionaryTrace	Q39054
PRO	PR:Q39054
Proteomes	UP000006548
Genevestigator	Q39054
GO	GO:0005829 GO:0005524 GO:0030151 GO:0061598 GO:0061599 GO:0009734 GO:0006777
Gene3D	2.40.340.10 3.40.980.10
InterPro	IPR020817 IPR008284 IPR005111 IPR005110 IPR001453
Pfam	PF00994 PF03454 PF03453
SMART	SM00852
SUPFAM	SSF53218 SSF63867 SSF63882
TIGRFAMs	TIGR00177
PROSITE	PS01078 PS01079

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005515	protein binding	PMID:23630326^[1]	ECO:0000021		UniProtKB:O22827	F		Table 1a and Figure 2a.	complete CACAO 8341
enables	GO:0008940	nitrate reductase activity	PMID:9990024^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	directly_regulates:(GO:0008940)	Seeded From UniProt	complete
involved_in	GO:0010038	response to metal ion	PMID:9990024^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(CHEBI:75215) causally_upstream_of:(GO:0008940)	Seeded From UniProt	complete
enables	GO:0030151	molybdenum ion binding	PMID:9341109^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009734	auxin-activated signaling pathway	PMID:15710899^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21166475^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0061599	molybdopterin molybdotransferase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10153 PANTHER:PTN000022760 RGD:69194	F		Seeded From UniProt	complete
enables	GO:0061598	molybdopterin adenylyltransferase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000022760 RGD:69194	F		Seeded From UniProt	complete
involved_in	GO:0032324	molybdopterin cofactor biosynthetic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000022759 UniProtKB:Q9NQX3	P		Seeded From UniProt	complete
involved_in	GO:0018315	molybdenum incorporation into molybdenum-molybdopterin complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10153 PANTHER:PTN000022760	P		Seeded From UniProt	complete
involved_in	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10153 MGI:MGI:109602 PANTHER:PTN000022760 RGD:69194 TAIR:locus:2147157 UniProtKB:G5EB65	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10153 PANTHER:PTN000022759 TAIR:locus:2147157 UniProtKB:P9WJQ7	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000022760 RGD:69194 WB:WBGene00003031	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000022759 RGD:69194 WB:WBGene00003031	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008940	P		Seeded From UniProt	complete
involved_in	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008284	P		Seeded From UniProt	complete
involved_in	GO:0032324	molybdopterin cofactor biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005110 InterPro:IPR005111 InterPro:IPR036135 InterPro:IPR036688	P		Seeded From UniProt	complete
enables	GO:0061598	molybdopterin adenylyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.75	F		Seeded From UniProt	complete
enables	GO:0061599	molybdopterin molybdotransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.10.1.1	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0501	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kaufholdt, D et al. (2013) Visualization and quantification of protein interactions in the biosynthetic pathway of molybdenum cofactor in Arabidopsis thaliana. J. Exp. Bot. 64 2005-16 PubMed GONUTS page
↑ ^2.0 ^2.1 Stallmeyer, B et al. (1999) The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 96 1333-8 PubMed GONUTS page
↑ Schwarz, G et al. (1997) Molybdenum cofactor biosynthesis. The plant protein Cnx1 binds molybdopterin with high affinity. J. Biol. Chem. 272 26811-4 PubMed GONUTS page
↑ Dai, X et al. (2005) Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 102 3129-34 PubMed GONUTS page
↑ Ito, J et al. (2011) Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J. Proteome Res. 10 1571-82 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23630326-1] Kaufholdt, D et al. (2013) Visualization and quantification of protein interactions in the biosynthetic pathway of molybdenum cofactor in Arabidopsis thaliana. J. Exp. Bot. 64 2005-16 PubMed GONUTS page

[PMID:9990024-2] 2.0 ^2.1 Stallmeyer, B et al. (1999) The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 96 1333-8 PubMed GONUTS page

[PMID:9341109-3] Schwarz, G et al. (1997) Molybdenum cofactor biosynthesis. The plant protein Cnx1 binds molybdopterin with high affinity. J. Biol. Chem. 272 26811-4 PubMed GONUTS page

[PMID:15710899-4] Dai, X et al. (2005) Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 102 3129-34 PubMed GONUTS page

[PMID:21166475-5] Ito, J et al. (2011) Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J. Proteome Res. 10 1571-82 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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ARATH:CNX1

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