AQUAE:O67450

Species (Taxon ID)	Aquifex aeolicus (strain VF5). (224324)
Gene Name(s)	dnaB (ECO:0000313 with EMBL:AAC07414.1)
Protein Name(s)	Replicative DNA helicase (ECO:0000256 with RuleBase:RU362085)
External Links
UniProt	O67450
EMBL	AE000657
PIR	H70427
RefSeq	NP_214015.1 WP_010880953.1
PDB	4NMN
PDBsum	4NMN
ProteinModelPortal	O67450
STRING	224324.aq_1472
EnsemblBacteria	AAC07414
GeneID	1192981
KEGG	aae:aq_1472
PATRIC	20960068
eggNOG	ENOG4105CDU COG0305
HOGENOM	HOG000113196
InParanoid	O67450
KO	K02314
OMA	WHESFID
OrthoDB	EOG6T4RW5
BioCyc	AAEO224324:GJBH-1056-MONOMER
Proteomes	UP000000798
GO	GO:0005829 GO:1990077 GO:0005524 GO:0003677 GO:0003678 GO:0046872 GO:0006269 GO:0006268
Gene3D	1.10.860.10 3.40.50.300
InterPro	IPR003593 IPR007692 IPR007694 IPR007693 IPR016136 IPR027417
Pfam	PF00772 PF03796
SMART	SM00382
SUPFAM	SSF48024 SSF52540
TIGRFAMs	TIGR00665
PROSITE	PS51199

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032508	DNA duplex unwinding	PMID:24373746	ECO:0000315			P		"When the dilated and constricted mutants were tested in a single-turnover, fork-unwinding assay with DnaC, the dilated mutant was able to produce ∼20% more unwound product as the wild-type helicase and did so at a slightly faster rate (Figure 5B). By contrast, while the constricted mutant could generate an amount of ssDNA comparable to that of wild-type DnaB, it took longer to do so (Figure 5B)."	complete CACAO 11910
involved_in	GO:0006268	DNA unwinding involved in DNA replication		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10236 PANTHER:PTN001248911	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10236 PANTHER:PTN001248911 UniProtKB:P9WMR3	C		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10236 PANTHER:PTN001248911	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007692	F		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007692 InterPro:IPR007693 InterPro:IPR007694 InterPro:IPR036185	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007692 InterPro:IPR007693 InterPro:IPR007694 InterPro:IPR036185	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007692 InterPro:IPR007693 InterPro:IPR007694 InterPro:IPR036185	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:1990077	primosome complex	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0639	C		Seeded From UniProt	complete
involved_in	GO:0006269	DNA replication, synthesis of RNA primer	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0639	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
part_of	GO:1990077	primosome complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000171759	C		Seeded From UniProt	complete
involved_in	GO:0006269	DNA replication, synthesis of RNA primer	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000171759	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000171759	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000171759	F		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000171759	F		Seeded From UniProt	complete
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