AGRFC:GCI

Species (Taxon ID)	Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacteriumtumefaciens (strain C58)). (176299)
Gene Name(s)	gci
Protein Name(s)	D-galactarolactone cycloisomerase
External Links
UniProt	A9CEQ8
EMBL	AE007870
PIR	AE2942 E98340
RefSeq	NP_357462.1 WP_010972789.1
PDB	4GGB 4HPN
PDBsum	4GGB 4HPN
ProteinModelPortal	A9CEQ8
STRING	176299.Atu3139
EnsemblBacteria	AAK90247
GeneID	1134941
KEGG	atu:Atu3139
PATRIC	20815744
eggNOG	ENOG4105CXK COG4948
HOGENOM	HOG000113756
KO	K18983
OrthoDB	EOG65BDGD
BioCyc	AGRO:ATU3139-MONOMER
UniPathway	UPA01050
Proteomes	UP000000813
GO	GO:0016853 GO:0046872 GO:0009063
Gene3D	3.20.20.120 3.30.390.10
InterPro	IPR029065 IPR029017 IPR018110 IPR013342 IPR013341 IPR001354
PANTHER	PTHR13794
Pfam	PF13378 PF02746
SMART	SM00922
SUPFAM	SSF51604 SSF54826
PROSITE	PS00908

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0003824	catalytic activity	PMID:24926996	ECO:0000269			F		A9CG74 has a DxH motif at the end of β-strand 3 similar to the catalytic residues in D-galactonate dehydratases (Figure 1) but does not catalyze the dehydration of D-galactonate; D-galactonate dehydratases do not catalyze the dehydration of m-galactarate or D-galacturonate. An alignment of the sequences in this cluster shows that both the active site catalytic residues and substrate binding residues in the capping domain are conserved (Figure 1). The enzymes in this cluster likely are orthologues based on sequence identity and shared catalytic/ substrate specificity-determining residues.	complete
Contributes to	GO:0009063	cellular amino acid catabolic process	PMID:22493433	ECO:0000314			P		Different pathways for d-galacturonate catabolism take place. It is active both on d-galactarolactone and d-glucarolactone, but does not work on the corresponding linear hexaric acid forms. These verifications are confirmed through the use of a gel (Fig. 2). Figure 1 shows the reaction scheme of the first steps of the oxidation pathways, which further clarify the function.	complete
involved_in	GO:0009063	cellular amino acid catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018110	P		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034618	F		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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References

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