AGGAC:Q7DK12

Species (Taxon ID)	Aggregatibacter actinomycetemcomitans (Actinobacillusactinomycetemcomitans) (Haemophilus actinomycetemcomitans). (714)
Gene Name(s)	cdtB (ECO:0000313 with EMBL:BAA35117.1)
Protein Name(s)	Cytolethal distending toxin (ECO:0000313 with EMBL:BAA35117.1) Cytolethal distending toxin B subunit (ECO:0000313 with EMBL:ACS74737.1)
External Links
UniProt	Q7DK12
EMBL	GQ231977 GQ231978 AB017807
PDB	2F2F
PDBsum	2F2F
SMR	Q7DK12
EvolutionaryTrace	Q7DK12
GO	GO:0044072 GO:0009405
Gene3D	3.60.10.10
InterPro	IPR003539 IPR005135
Pfam	PF03372
PIRSF	PIRSF018539
PRINTS	PR01388
SUPFAM	SSF56219

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0044072	negative regulation by symbiont of host cell cycle	PMID:10946289^[1]	ECO:0000315			P	Figures 4 and 5 show the effect of targeted modifications of cdt genes on immunoinhibition. Human T cells were incubated with proteins produced from the cdt mutant-carrying plasmids (schematic in figure 3), and the cell cycle distribution was analyzed. Of particular interest are Figures 5bc, which demonstrate the high levels of G2 arrest in the cdtB mutant.	complete CACAO 5291
involved_in	GO:0044072	negative regulation by symbiont of host cell cycle	PMID:10946289^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003539	P	Seeded From UniProt	complete
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↑ ^1.0 ^1.1 Shenker, BJ et al. (2000) Expression of the cytolethal distending toxin (Cdt) operon in Actinobacillus actinomycetemcomitans: evidence that the CdtB protein is responsible for G2 arrest of the cell cycle in human T cells. J. Immunol. 165 2612-8 PubMed GONUTS page