ADE05:Q2KRY6

Species (Taxon ID)	Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5). (28285)
Gene Name(s)	E4 (ECO:0000313 with EMBL:AAW65536.1)
Protein Name(s)	14.3 kDa protein (ECO:0000313 with EMBL:AAW65536.1)
External Links
UniProt	Q2KRY6
EMBL	AY601635
RefSeq	AP_000232.1
ProteinModelPortal	Q2KRY6
GO	GO:0016787 GO:0046080
Gene3D	2.70.40.10
InterPro	IPR029054 IPR008180
Pfam	PF00692
SUPFAM	SSF51283

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048525	negative regulation of viral reproduction	PMID:19129452	ECO:0000315			P		Figure 1. A-In the G1 phase, cells that were deleted for E1B and had E4orf1 had a large decrease in the amount of viral progeny within the cells compared to those that had E1B or were deleted for both E1B and E4orf1. Because more viral progeny were able to be made without both of than that if viruses only had E4orf1 it suggest that E4orf1 is restricting the ability to reproduce. The decreased PFU (figure1B) in the cells that had E4orf1 without E1B and E4orf2 suggest that is it E4orf1 that is negatively effecting the ability for viral replication (lanes 2 and 3). It is not seen in the presence of E1B which may stop the negative regulation ability of E4orf1, and when E4orf1 is gone, some viral reproduction ability recovers also suggests it is a negative regulator. It is IMP because of the use of mutated Adenovirus 5 that resulted in ultered phenotypes allowing comparison to determine the effects of specific proteins.	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.