ADE05:CAP6

Species (Taxon ID)	Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5). (28285)
Gene Name(s)	No Information Provided.
Protein Name(s)	Pre-protein VI pVI Endosome lysis protein Protease cofactor pVI-C
External Links
UniProt	P24937
EMBL	M73260
PIR	D39449
RefSeq	AP_000210.1
PDB	4CWU
PDBsum	4CWU
ProteinModelPortal	P24937
EvolutionaryTrace	P24937
PMAP-CutDB	P24937
Proteomes	UP000004992
GO	GO:0030430 GO:0042025 GO:0019028 GO:0046729 GO:0039664 GO:0075521 GO:0019076
InterPro	IPR004243
Pfam	PF02993

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0046729	viral procapsid	PMID:19782383^[1]	ECO:0000314			C	Figure 5C.	complete CACAO 6920
part_of	GO:0030430	host cell cytoplasm	PMID:14633984^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0019012	virion	PMID:25071205^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0039664	lysis of host organelle involved in viral entry into host cell	PMID:20409568^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039664	lysis of host organelle involved in viral entry into host cell	PMID:15681401^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0039664	lysis of host organelle involved in viral entry into host cell	PMID:22516138^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	PMID:14633984^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0046729	viral procapsid	PMID:19782383^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0019028	viral capsid	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004243	C	Seeded From UniProt	complete
involved_in	GO:0039664	lysis of host organelle involved in viral entry into host cell	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004243	P	Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	C	Seeded From UniProt	complete
involved_in	GO:0019076	viral release from host cell	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	P	Seeded From UniProt	complete
part_of	GO:0046729	viral procapsid	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	C	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	C	Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	C	Seeded From UniProt	complete
involved_in	GO:0039664	lysis of host organelle involved in viral entry into host cell	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	P	Seeded From UniProt	complete
part_of	GO:0019028	viral capsid	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	C	Seeded From UniProt	complete
involved_in	GO:0075521	microtubule-dependent intracellular transport of viral material towards nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000496186	P	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C	Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1162 UniProtKB-KW:KW-1160	P	Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
involved_in	GO:0039664	lysis of host organelle involved in viral entry into host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1174	P	Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C	Seeded From UniProt	complete
part_of	GO:0019028	viral capsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0167	C	Seeded From UniProt	complete
involved_in	GO:0075606	transport of viral material towards nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1176	P	Seeded From UniProt	complete
involved_in	GO:0075521	microtubule-dependent intracellular transport of viral material towards nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1177	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schoggins, JW & Falck-Pedersen, E (2009) Serotype 5 Adenovirus fiber (F7F41S) chimeric vectors incur packaging deficiencies when targeting peptides are inserted into Ad41 short fiber. Virology 395 10-20 PubMed GONUTS page
↑ ^2.0 ^2.1 Wodrich, H et al. (2003) Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals. EMBO J. 22 6245-55 PubMed GONUTS page
↑ Reddy, VS & Nemerow, GR (2014) Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection. Proc. Natl. Acad. Sci. U.S.A. 111 11715-20 PubMed GONUTS page
↑ Maier, O et al. (2010) An N-terminal domain of adenovirus protein VI fragments membranes by inducing positive membrane curvature. Virology 402 11-9 PubMed GONUTS page
↑ Wiethoff, CM et al. (2005) Adenovirus protein VI mediates membrane disruption following capsid disassembly. J. Virol. 79 1992-2000 PubMed GONUTS page
↑ Moyer, CL & Nemerow, GR (2012) Disulfide-bond formation by a single cysteine mutation in adenovirus protein VI impairs capsid release and membrane lysis. Virology 428 41-7 PubMed GONUTS page

[PMID:19782383-1] 1.0 ^1.1 Schoggins, JW & Falck-Pedersen, E (2009) Serotype 5 Adenovirus fiber (F7F41S) chimeric vectors incur packaging deficiencies when targeting peptides are inserted into Ad41 short fiber. Virology 395 10-20 PubMed GONUTS page

[PMID:14633984-2] 2.0 ^2.1 Wodrich, H et al. (2003) Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals. EMBO J. 22 6245-55 PubMed GONUTS page

[PMID:25071205-3] Reddy, VS & Nemerow, GR (2014) Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection. Proc. Natl. Acad. Sci. U.S.A. 111 11715-20 PubMed GONUTS page

[PMID:20409568-4] Maier, O et al. (2010) An N-terminal domain of adenovirus protein VI fragments membranes by inducing positive membrane curvature. Virology 402 11-9 PubMed GONUTS page

[PMID:15681401-5] Wiethoff, CM et al. (2005) Adenovirus protein VI mediates membrane disruption following capsid disassembly. J. Virol. 79 1992-2000 PubMed GONUTS page

[PMID:22516138-6] Moyer, CL & Nemerow, GR (2012) Disulfide-bond formation by a single cysteine mutation in adenovirus protein VI impairs capsid release and membrane lysis. Virology 428 41-7 PubMed GONUTS page

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ADE05:CAP6

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