ADE02:PRO

Species (Taxon ID)	Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2). (10515)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protease Adenain Adenovirus protease AVP Adenovirus proteinase Endoprotease
External Links
UniProt	P03252
EMBL	J01917
PIR	A03823
RefSeq	AP_000176.1 NP_040526.1
PDB	1AVP 1NLN 4EKF 4PID 4PIE
PDBsum	1AVP 1NLN 4EKF 4PID 4PIE
ProteinModelPortal	P03252
SMR	P03252
MEROPS	C05.001
GeneID	2652998
EvolutionaryTrace	P03252
Proteomes	UP000008167
GO	GO:0042025 GO:0019012 GO:0004197 GO:0008234 GO:0003677
Gene3D	3.40.395.10
InterPro	IPR000855
Pfam	PF00770
PIRSF	PIRSF001218
PRINTS	PR00703
ProDom	PD003705

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008234	cysteine-type peptidase activity	PMID:12758141	ECO:0000314			F		As seen in figure 5, AVP activity exhibited a complex sensitivity to carboxamidomethylation as a function of pH. One cysteine had a pKa of about 4.3. The most likely candidate for the low pKa is the conserved residue Cys122. Since five of the eight cysteines of AVP are buried in the interior of the molecule, the most likely candidate to be alkylated was one of the three cysteines found on the surface. Cys199 is only found in human adenovirus serotypes 2 and 5; it is located in a region of the molecule distant from either the pVIc binding site or the active site groove. Furthermore, mutation of Cys199 to Ser199 had no effect on enzyme activity (Brown and Mangel, unpublished). In the AVP–pVIc complex, Cys104 forms a disulfide bond with Cys10 of pVIc. Thus, there is now considerable evidence that Cys122 is the active site nucleophile of human adenovirus serotype 2 proteinase; this amino acid residue is conserved in all adenovirus serotypes.	complete CACAO 6541
enables	GO:0008234	cysteine-type peptidase activity	PMID:12758141	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000855	F		Seeded From UniProt	complete
	GO:0097282	immunoglobulin-mediated neutralization	PMID:22623776	ECO:0000314			P		fig 4 shows neutralization	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000855	P		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523799	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523799	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523799	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523799	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523799	C		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C		Seeded From UniProt	complete
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