ACACA:G8IIS4

Species (Taxon ID)	Acanthamoeba castellanii (Amoeba). (5755)
Gene Name(s)	Cyt (ECO:0000313 with EMBL:AET79741.1)
Protein Name(s)	Cysteine protease inhibitor (ECO:0000313 with EMBL:AET79741.1)
External Links
UniProt	G8IIS4
EMBL	JN793952
GO	GO:0005622 GO:0004869 GO:0008233
InterPro	IPR000010 IPR001713
Pfam	PF00031
PRINTS	PR00295
SMART	SM00043

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030414	peptidase inhibitor activity	PMID:23397569	ECO:0000314			F		Figure 1B and 1C show that the cysteine protease inhibitor inhibited human cathepsin L, human cathepsin B, and papain enzymes. All of these enzymes are part of the C1 family of cysteine proteinases, therefore showing that the cysteine protease inhibitor inhibits protease, or peptidase, activity.	complete CACAO 7629
	GO:0005764	lysosome	PMID:23397569	ECO:0000314			C		Figure two shows that the cysteine protease inhibitor, originally located in the cytoplasm, localizes to the lysosome during cyst formation.	complete CACAO 7632
part_of	GO:0005764	lysosome	PMID:23397569	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	PMID:23397569	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030414	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004869	P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004866	P		Seeded From UniProt	complete
enables	GO:0004866	endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001713	F		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000010	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
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