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9HEPC:Q91RS4

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Species (Taxon ID) Hepatitis C virus. (11103)
Gene Name(s) No Information Provided.
Protein Name(s) NS3 protease (ECO:0000313 with EMBL:AAK54554.1)
External Links
UniProt Q91RS4
EMBL AF369229
PDB 2A4Q
2F9U
2OBO
2P59
2XCN
PDBsum 2A4Q
2F9U
2OBO
2P59
2XCN
ProteinModelPortal Q91RS4
DrugBank DB06290
euHCVdb AF369229
EvolutionaryTrace Q91RS4
GO GO:0046872
GO:0008236
GO:0019087
InterPro IPR004109
IPR009003
Pfam PF02907
SUPFAM SSF50494

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008236

serine-type peptidase activity

PMID:8189513[1]

ECO:0000315

F

Figure 4. Demonstrates replacing the catalytic serine with an alanine results in a loss of self-cleavage.

complete
CACAO 10356

GO:0097264

self proteolysis

PMID:8189513[1]

ECO:0000314

P

Figure 4. Demonstrates the peptide is capable of undergoing self-cleavage.

complete
CACAO 10363

involved_in

GO:0097264

self proteolysis

PMID:8189513[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

PMID:8189513[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004109

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004109

F

Seeded From UniProt

complete

involved_in

GO:0019087

transformation of host cell by virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004109

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Failla, C et al. (1994) Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J. Virol. 68 3753-60 PubMed GONUTS page