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9CAUD:R9VY83
Contents
Species (Taxon ID) | Paenibacillus phage phiIBB_Pl23. (1337877) | |
Gene Name(s) | No Information Provided. | |
Protein Name(s) | N-acetylmuramoyl-L-alanine amidase (ECO:0000313 with EMBL:AGN89335.1) | |
External Links | ||
UniProt | R9VY83 | |
EMBL | KF010834 | |
RefSeq | YP_008320357.1 | |
GeneID | 16385281 | |
KEGG | vg:16385281 | |
Proteomes | UP000014424 | |
GO | GO:0008745 GO:0009253 | |
CDD | cd06583 | |
Gene3D | 3.40.80.10 | |
InterPro | IPR002502 | |
Pfam | PF01510 | |
SMART | SM00644 | |
SUPFAM | SSF55846 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0008745 |
N-acetylmuramoyl-L-alanine amidase activity |
ECO:0000314 |
F |
The authors claim that 'BlastP, Pfam and HHpred identified an N-acetylmuramoyl-L-alanine amidase belonging to the Amidase_2 family (Pfam 01510) at the N-terminus encompassing two third of the protein. CDD database identified 5 putative amidase catalytic residues: two histidines (position 29 and 129), a phenylalanine (position 53), a lysine (position 135) and a cysteine (position 137)' (First paragraph of the results section). Table 2 however confirmed that PlyPl23 has lytic activity and also shows the lytic spectrum of PlyPl23 when assessed against a panel of 20 P. larvae isolates and 4 additional strains belonging to other related bacterial species (Bacillus cereus, Lactobacillus paracasei, Lactobacillus pentosus, Bacillus subtilis), and compared with that of the respective phage phiIBB_Pl23. Results showed that while the phage phiIBB_Pl23 was able to lyse 16 of the 20 strains (80%), its endolysin (PlyPl23) was active against all the tested Paenibacillus larvae strains. The Bacillus and Lactobacillus strains were not lysed by the phage or by the enzyme |
complete | |||||
enables |
GO:0008745 |
N-acetylmuramoyl-L-alanine amidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009253 |
peptidoglycan catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008745 |
N-acetylmuramoyl-L-alanine amidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Oliveira, A et al. (2015) The First Paenibacillus larvae Bacteriophage Endolysin (PlyPl23) with High Potential to Control American Foulbrood. PLoS ONE 10 e0132095 PubMed GONUTS page