9ASCO:F1T2J9

Species (Taxon ID)	Wickerhamia fluorescens. (45790)
Gene Name(s)	pprA (ECO:0000313 with EMBL:BAK09193.1)
Protein Name(s)	Phenylpyruvate reductase (ECO:0000313 with EMBL:BAK09193.1)
External Links
UniProt	F1T2J9
EMBL	AB621792
ProteinModelPortal	F1T2J9
GO	GO:0051287 GO:0016616
Gene3D	3.40.50.720
InterPro	IPR006139 IPR006140 IPR016040
Pfam	PF00389 PF02826

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	PMID:21672638	ECO:0000314			F		Figure 1: Time dependent changes in PLA levels were monitored using HPLC. The PLA concentration linearly increased (Fig. 1A), indicating that the strain produced PLA at a constant rate. Adding PPA, a potential PLA substrate, to the culture medium increased the amount of PLA produced by strain TK1 (Fig. 1B). After 48-h of culture, 1.5 mM PPA was consumed and 0.8 mM of PLA accumulated in the medium,indicating that 53% of the PPA was converted to PLA. When cultured in MM containing phenylalanine, strain TK1 consumed phenylalanine and produced PLA (Fig. 1C). After the initial 24-h of incubation, 5.0 mMphenylalanine was consumed and 5.7 mMPLA was generated,indicating that most of the added phenylalanine was converted to PLA. We detected phenylalanine aminotransferase (PAT) (1.9±0.2 μmol min−1 mg−1) and PPR (see below) activities in the fungal cell-free extracts. These results together with the higher levels of PLA being generated from either PPA or phenylalanine than from glucose when added as a carbon source, indicated that the fungus generates PLA via PPA and/or phenylalanine (Fig. 1D), and that biosynthesized PPA limits PLA production from glucose.	complete CACAO 4833
enables	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006139	F		Seeded From UniProt	complete
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006139 InterPro:IPR006140	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006139 InterPro:IPR006140	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
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References

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