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Category:GO:0004325 ! ferrochelatase activity
name: ferrochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22587]
subset: gosubset_prok
synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1]
synonym: "heme synthase activity" EXACT [EC:4.99.1.1]
synonym: "heme synthetase activity" EXACT [EC:4.99.1.1]
synonym: "iron chelatase activity" EXACT [EC:4.99.1.1]
synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1]
synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1]
synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1]
xref: EC:4.99.1.1
xref: KEGG:R00310
xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN
xref: Reactome:REACT_102151 "Ferrous iron is inserted into protoporphyrin IX to form heme, Schizosaccharomyces pombe"
xref: Reactome:REACT_103500 "Ferrous iron is inserted into protoporphyrin IX to form heme, Drosophila melanogaster"
xref: Reactome:REACT_113497 "Ferrous iron is inserted into protoporphyrin IX to form heme, Oryza sativa"
xref: Reactome:REACT_115167 "Ferrous iron is inserted into protoporphyrin IX to form heme, Arabidopsis thaliana"
xref: Reactome:REACT_115628 "protoporphyrin IX + Fe++ => heme + 2 H+, Gallus gallus"
xref: Reactome:REACT_31724 "Ferrous iron is inserted into protoporphyrin IX to form heme, Mus musculus"
xref: Reactome:REACT_34447 "Ferrous iron is inserted into protoporphyrin IX to form heme, Mycobacterium tuberculosis"
xref: Reactome:REACT_52193 "Ferrous iron is inserted into protoporphyrin IX to form heme, Plasmodium falciparum"
xref: Reactome:REACT_77614 "Ferrous iron is inserted into protoporphyrin IX to form heme, Xenopus tropicalis"
xref: Reactome:REACT_78000 "Ferrous iron is inserted into protoporphyrin IX to form heme, Dictyostelium discoideum"
xref: Reactome:REACT_78120 "Ferrous iron is inserted into protoporphyrin IX to form heme, Canis familiaris"
xref: Reactome:REACT_80925 "Ferrous iron is inserted into protoporphyrin IX to form heme, Rattus norvegicus"
xref: Reactome:REACT_83976 "Ferrous iron is inserted into protoporphyrin IX to form heme, Sus scrofa"
xref: Reactome:REACT_87767 "Ferrous iron is inserted into protoporphyrin IX to form heme, Escherichia coli"
xref: Reactome:REACT_90534 "Ferrous iron is inserted into protoporphyrin IX to form heme, Danio rerio"
xref: Reactome:REACT_92687 "Ferrous iron is inserted into protoporphyrin IX to form heme, Gallus gallus"
xref: Reactome:REACT_93298 "Ferrous iron is inserted into protoporphyrin IX to form heme, Staphylococcus aureus N315"
xref: Reactome:REACT_9461 "Ferrous iron is inserted into protoporphyrin IX to form heme, Homo sapiens"
xref: Reactome:REACT_96094 "Ferrous iron is inserted into protoporphyrin IX to form heme, Saccharomyces cerevisiae"
xref: Reactome:REACT_96730 "Ferrous iron is inserted into protoporphyrin IX to form heme, Taeniopygia guttata"
xref: Reactome:REACT_97060 "Ferrous iron is inserted into protoporphyrin IX to form heme, Bos taurus"
xref: RHEA:22587
is_a: GO:0016829 ! lyase activity
AmiGO
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