GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
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Cacao
| GO:0004713 | protein tyrosine kinase activity | PMID:21703394 | IMP: Inferred from Mutant Phenotype | F | ||||
| This annotation made on page: By: Sejal (group Team UCL-Maple Leafs) on 2011-10-09 10:22:21 CDT. | ||||||||
You must be logged in to challenge this annotation.
| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Emlarkin03, Team Angry Squirrels | 2011-11-22 19:36:35 CST | A more appropriate go term. | None, yet. |
| Public Assessment | Sgouni | 2011-10-25 20:36:41 CDT | I thought this was a tricky annotation. When FAK is autophosphorylated, it creates a binding site for SRC which in turn is activated by phosphorylation of Y416 (SRC's active site). Fig 3 shows that SRC protein expression and phosphorylation is decreased in autistic lymphoblasts. However it does not show that FAK1 has protein tyrosine kinase activity. It seems more like FAK receives a phosphorylation signal, undergoes a conformational change and which increases the affinity for SRC. | Unacceptable |
