Cacao

This annotation has been flagged because it has been edited since last assessment

This annotation has been flagged because it has been edited since last assessment

You are combining sequence alignment, molecular modeling and crystallography statistics into one annotation. Let's look at those three parts. Sequence alignment: "The Catalytic domain of XylA has a 45% identity with PlyL." What kind of identity is this? What/where is the evidence? How does this support the GO Term you chose?

Molecular modeling: "There is also a very large similarity in their overall backbones." " In Figure 2B the presence of a very similar construction in both XylA CAT(blue) and PlyL CAT(green) is demonstrated." Can you put 'very large similarity' into more quantitative or scientific words? What kind of similarity is this, and how do you know? What kind of experiment was done in Figure 2B? What/where is the evidence? How does this support the GO Term you chose?

Crystallography statistics: "Table 2 displays the similarities between XylA CAT, XylA CAT+5K, And PlyBa04 CAT. Both the catalytic domain of XylA and PlyL have high lysing activity. The authors of this paper used experimental evidence found in Table 2 to illustrate the similarities in the charge as well as makeup of the catalytic domains of XylA CAT, XylA CAT+5K, And PlyBa04 CAT respectively.The net charge is directly related to the lytic activity and crystal structure found in Table 2." How do we know net charge is directly related to lytic activity (this relates to your GO Term)? How do we know the catalytic domains have high lysing activity? I'm not sure Table 2 supports your GO Term but you have some interesting statements here that sound like they have potential if you can improve your description.