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Colocalizes withGO:0005899insulin receptor complexPMID:26063811IDA: Inferred from Direct Assay C
This annotation made on page: HUMAN:PTPRJ
By: CSears (group Team Girl, you trypsin) on 2017-02-14 13:45:43 CST.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeCSears,
Team Girl, you trypsin
2017-03-07 13:32:49 CST

According to the GO annotation conventions, "Gene products that are transiently or peripherally associated with an organelle or complex may be annotated to the relevant cellular component term, using the colocalizes_with qualifier. This qualifier may also be used in cases where the resolution of an assay is not accurate enough to say that the gene product is a bona fide component member." Ptprj is not a component of the insulin receptor complex; it does, however, associate with the insulin receptor. Because of this, the colocalizes_with qualifier is necessary for the annotation to be accurate.

None, yet.
ChallengeTheBockster,
Team Daytona Bronze Viper
2017-03-07 13:05:37 CST

There should be no qualifier. Furthermore, the Go term should be GO:0009986 (cell surface). This is because the article states that "Ptprj co-localized with the IR at the *cell surface* before and after the insulin stimulation (Fig. 3C, data not shown). "

None, yet.
ChallengeSarahCouv,
Team Lily Whale
2017-02-24 15:41:51 CST

The protein for this annotation is incorrect. I believe he has the right protein, but the wrong organism to go with the protein, which makes the whole thing incorrect. I believe the correct protein is Q64455 (PTPRJ_MOUSE).

0
Private
Assessment
JimHu2017-03-21 13:29:51 CDTYou need to be an instructor to view these notes.Acceptable
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Public
Assessment
DanielRenfro2017-03-07 13:32:49 CST

This annotation has been flagged because it has been challenged since last assessment

Flagged
Public
Assessment
DanielRenfro2017-03-07 13:05:37 CST

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
Suzialeksander2017-03-03 15:26:49 CSTYou need to be an instructor to view these notes.Requires Changes
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Public
Assessment
DanielRenfro2017-02-24 15:41:51 CST

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
Sandyl 272017-02-23 12:28:02 CSTYou need to be an instructor to view these notes.Requires Changes
Protein