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Membrane terms as of 2008-11-20

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Return to Compilation of GO Term Documentation [1]

GO:0016020 membrane

    • GO:0044425 membrane part
        • GO:0031224 intrinsic to membrane (Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. [source: GOC:mah] Comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.)
            • GO:0031225 anchored to membrane (Tethered to a membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane. [source: GOC:mah])
                • GO:0046658 anchored to plasma membrane (Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane. [source: GOC:mah])
                • GO:0031362 anchored to external side of plasma membrane
            • GO:0016021 integral to membrane (Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. [source: GOC:go_curators] Compare to definition from Component Ontology: "proteins in which some part of the peptide sequence spans all or part of the membrane (in theory, it could also be used for RNAs embedded in a membrane, if any such exist)"
                • GO:0009319 cytochrome o ubiquinol oxidase complex
                • GO:0045203 integral to outer membrane
                • GO:0031301 integral to organelle membrane
                • GO:0005887 integral to plasma membrane
                • GO:0034702 ion channel complex
                • GO:0046696 lipopolysaccharide receptor complex
                • GO:0017090 meprin A complex
                • GO:0046930 pore complex
                • GO:0016472 sodium ion-transporting two-sector ATPase complex
            • GO:0031230 intrinsic to cell outer membrane
                • GO:0045203 integral to cell outer membrane
                • GO:0031243 intrinsic to external side of cell outer membrane
                • GO:0031246 intrinsic to internal side of cell outer membrane
            • GO:0031300 intrinsic to organelle membrane
                • GO:0031301 integral to organelle membrane
                • GO:0031227 intrinsic to endoplasmic reticulum membrane
                    • GO:003017 integral to endoplasmic reticulum membrane
                • GO:0031302 intrinsic to endosome membrane
                • etc.
            • GO:0031226 intrinsic to plasma membrane (Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. [source: GOC:mah])
                • GO:0046658 anchored to plasma membrane (Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane. [source: GOC:mah])
                    • GO:0031362 anchored to external side of plasma membrane
                • GO:0005887 integral to plasma membrane (Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. [source: GOC:go_curators])
                    • many GO terms for individual membrane complexes
                • GO:0031233 intrinsic to external side of plasma membrane
                • GO:0031235 intrinsic to internal side of plasma membrane

From Component Ontology Guidelines

  • GO:0031224 Intrinsic to membrane: "refers to gene products that have some covalently attached moiety embedded in the membrane, and is further split into integral to membrane ; GO:0016021 and anchored to membrane ; GO:0031225. The former refers to proteins in which some part of the peptide sequence spans all or part of the membrane (in theory, it could also be used for RNAs embedded in a membrane, if any such exist); the latter refers to gene products tethered to a membrane by a covalently attached anchor, such as a lipid moiety, which is embedded in the membrane."