Category:GO:0004491 ! methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

name: methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product." [EC:1.2.1.27, PMID:2768248]
synonym: "methylmalonate-semialdehyde dehydrogenase (acylating) activity" RELATED []
synonym: "MMSA dehydrogenase activity" RELATED [EC:1.2.1.27]
synonym: "MSDH activity" RELATED [EC:1.2.1.27]
xref: EC:1.2.1.27
xref: MetaCyc:1.2.1.27-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AmiGO <GOterm>GO:0004491</GOterm>
Gene Ontology Home