Category:GO:0003840 ! obsolete gamma-glutamyltransferase activity

This GO term has been obsoleted. Do not annotate to it.

id: GO:0003840
name: obsolete gamma-glutamyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
comment: This term was obsoleted because it does not correspond to a physiological reaction.nUsage comment: The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity).
synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" RELATED [EC:2.3.2.2]
synonym: "alpha-glutamyl transpeptidase activity" RELATED [EC:2.3.2.2]
synonym: "gamma-glutamyl peptidyltransferase activity" RELATED [EC:2.3.2.2]
synonym: "gamma-glutamyl transpeptidase activity" RELATED [EC:2.3.2.2]
synonym: "gamma-GPT" RELATED [EC:2.3.2.2]
synonym: "gamma-GT" RELATED [EC:2.3.2.2]
synonym: "gamma-GTP" RELATED [EC:2.3.2.2]
synonym: "glutamyl transpeptidase activity" RELATED [EC:2.3.2.2]
synonym: "L-gamma-glutamyl transpeptidase activity" RELATED [EC:2.3.2.2]
synonym: "L-gamma-glutamyltransferase activity" RELATED [EC:2.3.2.2]
synonym: "L-glutamyltransferase activity" RELATED [EC:2.3.2.2]
xref: EC:2.3.2.2
xref: KEGG_REACTION:R04159
xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN
is_obsolete: true
consider: GO:0036374 ! glutathione hydrolase activity

AmiGO <GOterm>GO:0003840</GOterm>
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