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RAT:GBRA1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Gabra1 (synonyms: Gabra-1)
Protein Name(s) Gamma-aminobutyric acid receptor subunit alpha-1

GABA(A) receptor subunit alpha-1

External Links
UniProt P62813
EMBL L08490
AY574250
BC100061
PIR JQ0158
RefSeq NP_899155.1
XP_006246185.1
XP_006246186.1
UniGene Rn.28463
ProteinModelPortal P62813
SMR P62813
BioGrid 248322
IntAct P62813
MINT MINT-3371441
STRING 10116.ENSRNOP00000004725
BindingDB P62813
ChEMBL CHEMBL343
GuidetoPHARMACOLOGY 404
PhosphoSite P62813
PRIDE P62813
Ensembl ENSRNOT00000004725
GeneID 29705
KEGG rno:29705
UCSC RGD:61855
CTD 2554
RGD 61855
eggNOG NOG238757
GeneTree ENSGT00760000119010
HOGENOM HOG000231337
HOVERGEN HBG051707
InParanoid P62813
KO K05175
OMA APNIARD
OrthoDB EOG7JX342
PhylomeDB P62813
TreeFam TF315453
Reactome REACT_199021
REACT_199029
REACT_270861
NextBio 285923
PRO PR:P62813
Proteomes UP000002494
Genevestigator P62813
GO GO:0030054
GO:0034707
GO:1902710
GO:0005887
GO:0045211
GO:0008503
GO:0005254
GO:0008144
GO:0004890
GO:0005237
GO:0071420
GO:0006821
GO:0007214
GO:0034220
GO:0051932
Gene3D 2.70.170.10
InterPro IPR006028
IPR001390
IPR005431
IPR006202
IPR006201
IPR006029
IPR018000
PANTHER PTHR18945
Pfam PF02931
PF02932
PRINTS PR01079
PR01614
PR00253
PR00252
SUPFAM SSF63712
SSF90112
TIGRFAMs TIGR00860
PROSITE PS00236

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1904862

inhibitory synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62812

P

Seeded From UniProt

complete

contributes_to

GO:0022851

GABA-gated chloride ion channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62812

F

Seeded From UniProt

complete

part_of

GO:1902710

GABA receptor complex

PMID:12930820[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071420

cellular response to histamine

PMID:18281286[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1902711

GABA-A receptor complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14867

C

Seeded From UniProt

complete

involved_in

GO:0051932

synaptic transmission, GABAergic

PMID:12930820[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0016917

GABA receptor activity

PMID:12930820[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0099060

integral component of postsynaptic specialization membrane

PMID:8876241[3]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0099060

integral component of postsynaptic specialization membrane

PMID:8613776[4]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0099060

integral component of postsynaptic specialization membrane

PMID:21073549[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

PMID:8876241[3]

ECO:0006003

electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

PMID:8613776[4]

ECO:0006003

electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0002037)

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

PMID:21073549[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:1346133[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:15152020[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:1904315

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95613
PANTHER:PTN000436343

F

Seeded From UniProt

complete

part_of

GO:1902711

GABA-A receptor complex

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95623
PANTHER:PTN001055383
UniProtKB:P14867
UniProtKB:P47869
UniProtKB:P78334

C

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95623
PANTHER:PTN001055383
UniProtKB:P14867
UniProtKB:P47869

P

Seeded From UniProt

complete

part_of

GO:0098794

postsynapse

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95614
PANTHER:PTN000436343

C

Seeded From UniProt

complete

involved_in

GO:0060078

regulation of postsynaptic membrane potential

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95613
PANTHER:PTN000436343

P

Seeded From UniProt

complete

involved_in

GO:0051932

synaptic transmission, GABAergic

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000436343
RGD:61855
RGD:61861
RGD:61966

P

Seeded From UniProt

complete

involved_in

GO:0050877

nervous system process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87888
PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P43681

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
UniProtKB:G5EDF1
UniProtKB:P11230
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
RGD:2351
RGD:621544
WB:WBGene00000042
WB:WBGene00002974
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

involved_in

GO:0042391

regulation of membrane potential

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87885
MGI:MGI:87887
MGI:MGI:87888
MGI:MGI:87890
MGI:MGI:87891
MGI:MGI:87892
MGI:MGI:87893
MGI:MGI:87894
MGI:MGI:87895
MGI:MGI:95747
MGI:MGI:95751
MGI:MGI:99779
PANTHER:PTN000434994
RGD:2348
UniProtKB:P02708
UniProtKB:P23415

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95613
PANTHER:PTN000434994
UniProtKB:P23416
UniProtKB:P36544
UniProtKB:Q401N2
WB:WBGene00000055
WB:WBGene00002974
WB:WBGene00006797

P

Seeded From UniProt

complete

part_of

GO:0032590

dendrite membrane

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000436343
RGD:61856
RGD:61966

C

Seeded From UniProt

complete

enables

GO:0022851

GABA-gated chloride ion channel activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000436343
RGD:61861
UniProtKB:P14867
UniProtKB:P47869
UniProtKB:P78334

F

Seeded From UniProt

complete

contributes_to

GO:0008503

benzodiazepine receptor activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001055383
RGD:61861
UniProtKB:P47869

F

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003011
FB:FBgn0086778
MGI:MGI:103156
MGI:MGI:95613
MGI:MGI:95623
MGI:MGI:95747
PANTHER:PTN000434994
RGD:2648
RGD:61859
RGD:61901
UniProtKB:P48167
WB:WBGene00000050
WB:WBGene00000054

P

Seeded From UniProt

complete

involved_in

GO:0007214

gamma-aminobutyric acid signaling pathway

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95623
PANTHER:PTN001055383
RGD:68320
UniProtKB:P47869

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P30926
UniProtKB:P32297
UniProtKB:P36544
UniProtKB:P43681
UniProtKB:Q15822

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861899
MGI:MGI:95623
MGI:MGI:95750
PANTHER:PTN000434994
RGD:2649
RGD:2650
RGD:61855
RGD:61861
RGD:621229
UniProtKB:O75311
UniProtKB:P23415
UniProtKB:P23416
UniProtKB:P28472
UniProtKB:P48167
UniProtKB:Q9UGM1
WB:WBGene00000955
WB:WBGene00001133
WB:WBGene00001591
WB:WBGene00001592

C

Seeded From UniProt

complete

enables

GO:0005254

chloride channel activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95623
PANTHER:PTN001055383
RGD:61966
RGD:621735

F

Seeded From UniProt

complete

enables

GO:0005237

inhibitory extracellular ligand-gated ion channel activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001055383
RGD:61861

F

Seeded From UniProt

complete

contributes_to

GO:0005230

extracellular ligand-gated ion channel activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
WB:WBGene00000043
WB:WBGene00001512
WB:WBGene00003386
WB:WBGene00006774
WB:WBGene00012857
WB:WBGene00017375

F

Seeded From UniProt

complete

contributes_to

GO:0004890

GABA-A receptor activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95623
PANTHER:PTN001055383
RGD:2648
RGD:61859
RGD:61861
RGD:61966
RGD:621732
RGD:621735
RGD:68320

F

Seeded From UniProt

complete

involved_in

GO:1904862

inhibitory synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14867
ensembl:ENSP00000377517

P

Seeded From UniProt

complete

part_of

GO:1902711

GABA-A receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14867
ensembl:ENSP00000377517

C

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14867
ensembl:ENSP00000377517

P

Seeded From UniProt

complete

enables

GO:0022851

GABA-gated chloride ion channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14867
ensembl:ENSP00000377517

F

Seeded From UniProt

complete

involved_in

GO:1904862

inhibitory synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62812
ensembl:ENSMUSP00000020707

P

Seeded From UniProt

complete

enables

GO:1904315

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62812
ensembl:ENSMUSP00000020707

F

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62812
ensembl:ENSMUSP00000020707

C

Seeded From UniProt

complete

involved_in

GO:0060078

regulation of postsynaptic membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62812
ensembl:ENSMUSP00000020707

P

Seeded From UniProt

complete

enables

GO:0022851

GABA-gated chloride ion channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62812
ensembl:ENSMUSP00000020707

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62812
ensembl:ENSMUSP00000020707

C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006028
InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0004890

GABA-A receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001390
InterPro:IPR005431

F

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001390
InterPro:IPR006028
InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0005230

extracellular ligand-gated ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006202
InterPro:IPR036734

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001390
InterPro:IPR006029
InterPro:IPR006202
InterPro:IPR036719
InterPro:IPR036734

P

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005431

P

Seeded From UniProt

complete

involved_in

GO:0007214

gamma-aminobutyric acid signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005431

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001390

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005431
InterPro:IPR006028
InterPro:IPR006029
InterPro:IPR006201
InterPro:IPR006202
InterPro:IPR036719
InterPro:IPR036734

C

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006028
InterPro:IPR006201

P

Seeded From UniProt

complete

enables

GO:0008503

benzodiazepine receptor activity

PMID:1346133[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007214

gamma-aminobutyric acid signaling pathway

PMID:1346133[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

PMID:1346133[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005237

inhibitory extracellular ligand-gated ion channel activity

PMID:1346133[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004890

GABA-A receptor activity

PMID:11161482[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-RNO-8856390

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0628
UniProtKB-SubCell:SL-0219

C

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

P

Seeded From UniProt

complete

enables

GO:0005254

chloride channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

F

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0034707

chloride channel complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page
  2. Saras, A et al. (2008) Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J. Biol. Chem. 283 10470-5 PubMed GONUTS page
  3. 3.0 3.1 Nusser, Z et al. (1996) Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proc. Natl. Acad. Sci. U.S.A. 93 11939-44 PubMed GONUTS page
  4. 4.0 4.1 Nusser, Z et al. (1996) The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J. Neurosci. 16 103-14 PubMed GONUTS page
  5. 5.0 5.1 Kasugai, Y et al. (2010) Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Eur. J. Neurosci. 32 1868-88 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Wieland, HA et al. (1992) A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267 1426-9 PubMed GONUTS page
  7. Feng, HJ & Macdonald, RL (2004) Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. J. Neurophysiol. 92 1577-85 PubMed GONUTS page
  8. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. Saha, S et al. (2001) Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. Mol. Cell. Neurosci. 17 241-57 PubMed GONUTS page